Titre
Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Dubey, L.K.
Auteure/Auteur
Karempudi, P.
Auteure/Auteur
Luther, S.A.
Auteure/Auteur
Ludewig, B.
Auteure/Auteur
Harris, N.L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2041-1723
Statut éditorial
Publié
Date de publication
2017-08-28
Volume
8
Numéro
1
Première page
367
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Lymphatic growth (lymphangiogenesis) within lymph nodes functions to promote dendritic cell entry and effector lymphocyte egress in response to infection or inflammation. Here we demonstrate a crucial role for lymphotoxin-beta receptor (LTβR) signaling to fibroblastic reticular cells (FRCs) by lymphotoxin-expressing B cells in driving mesenteric lymph node lymphangiogenesis following helminth infection. LTβR ligation on fibroblastic reticular cells leads to the production of B-cell-activating factor (BAFF), which synergized with interleukin-4 (IL-4) to promote the production of the lymphangiogenic factors, vascular endothelial growth factors (VEGF)-A and VEGF-C, by B cells. In addition, the BAFF-IL-4 synergy augments expression of lymphotoxin by antigen-activated B cells, promoting further B cell-fibroblastic reticular cell interactions. These results underlie the importance of lymphotoxin-dependent B cell-FRC cross talk in driving the expansion of lymphatic networks that function to promote and maintain immune responsiveness.The growth of lymph nodes in response to infection requires lymphangiogenesis. Dubey et al. show that the mesenteric lymph node lymphangiogenesis upon helminth infection depends on the signaling loop between the B and fibroblastic reticular cells (FRCs), whereby the FRCs respond to lymphotoxin secreted by B cells by releasing B cell activating factor.
Sujets
PID Serval
serval:BIB_DE11D4AF0AD2
PMID
Open Access
Oui
Date de création
2017-09-12T11:56:04.640Z
Date de création dans IRIS
2025-05-21T05:07:53Z
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Nom
s41467-017-00504-9.pdf
Version du manuscrit
published
Taille
10.26 MB
Format
Adobe PDF
PID Serval
serval:BIB_DE11D4AF0AD2.P001
URN
urn:nbn:ch:serval-BIB_DE11D4AF0AD23
Somme de contrôle
(MD5):f935ab16f8d1f157c78c4918097ae6f0