Titre
Treatment-Naive Individuals Are the Major Source of Transmitted HIV-1 Drug Resistance in Men Who Have Sex With Men in the Swiss HIV Cohort Study.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Drescher, S.M.
Auteure/Auteur
von Wyl, V.
Auteure/Auteur
Yang, W.L.
Auteure/Auteur
Böni, J.
Auteure/Auteur
Yerly, S.
Auteure/Auteur
Shah, C.
Auteure/Auteur
Aubert, V.
Auteure/Auteur
Klimkait, T.
Auteure/Auteur
Taffé, P.
Auteure/Auteur
Furrer, H.
Auteure/Auteur
Battegay, M.
Auteure/Auteur
Ambrosioni, J.
Auteure/Auteur
Cavassini, M.
Auteure/Auteur
Bernasconi, E.
Auteure/Auteur
Vernazza, P.L.
Auteure/Auteur
Ledergerber, B.
Auteure/Auteur
Günthard, H.F.
Auteure/Auteur
Kouyos, R.D.
Auteure/Auteur
Contributrices/contributeurs
Aubert, V.
Barth, J.
Battegay, M.
Bernasconi, E.
Böni, J.
Bucher, HC.
Burton-Jeangros, C.
Calmy, A.
Cavassini, M.
Egger, M.
Elzi, L.
Fehr, J.
Fellay, J.
Furrer, H.
Fux, CA.
Gorgievski, M.
Günthard, H.
Haerry, D.
Hasse, B.
Hirsch, HH.
Hösli, I.
Kahlert, C.
Kaiser, L.
Keiser, O.
Klimkait, T.
Kovari, H.
Kouyos, R.
Ledergerber, B.
Martinetti, G.
Martinez de Tejada, B.
Metzner, K.
Müller, N.
Nadal, D.
Pantaleo, G.
Rauch, A.
Regenass, S.
Rickenbach, M.
Rudin, C.
Schmid, P.
Schultze, D.
Schöni-Affolter, F.
Schüpbach, J.
Speck, R.
Staehelin, C.
Tarr, P.
Telenti, A.
Trkola, A.
Vernazza, P.
Weber, R.
Yerly, S.
Groupes de travail
Swiss HIV Cohort Study
Liens vers les personnes
Liens vers les unités
ISSN
1537-6591
Statut éditorial
Publié
Date de publication
2014
Volume
58
Numéro
2
Première page
285
Dernière page/numéro d’article
294
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Background. Human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) can compromise antiretroviral therapy (ART) and thus represents an important public health concern. Typically, sources of TDR remain unknown, but they can be characterized with molecular epidemiologic approaches. We used the highly representative Swiss HIV Cohort Study (SHCS) and linked drug resistance database (SHCS-DRDB) to analyze sources of TDR. Methods. ART-naive men who have sex with men with infection date estimates between 1996 and 2009 were chosen for surveillance of TDR in HIV-1 subtype B (N = 1674), as the SHCS-DRDB contains pre-ART genotypic resistance tests for >69% of this surveillance population. A phylogeny was inferred using pol sequences from surveillance patients and all subtype B sequences from the SHCS-DRDB (6934 additional patients). Potential sources of TDR were identified based on phylogenetic clustering, shared resistance mutations, genetic distance, and estimated infection dates. Results. One hundred forty of 1674 (8.4%) surveillance patients carried virus with TDR; 86 of 140 (61.4%) were assigned to clusters. Potential sources of TDR were found for 50 of 86 (58.1%) of these patients. ART-naive patients constitute 56 of 66 (84.8%) potential sources and were significantly overrepresented among sources (odds ratio, 6.43 [95% confidence interval, 3.22-12.82]; P < .001). Particularly large transmission clusters were observed for the L90M mutation, and the spread of L90M continued even after the near cessation of antiretroviral use selecting for that mutation. Three clusters showed evidence of reversion of K103N or T215Y/F. Conclusions. Many individuals harboring viral TDR belonged to transmission clusters with other Swiss patients, indicating substantial domestic transmission of TDR in Switzerland. Most TDR in clusters could be linked to sources, indicating good surveillance of TDR in the SHCS-DRDB. Most TDR sources were ART naive. This, and the presence of long TDR transmission chains, suggests that resistance mutations are frequently transmitted among untreated individuals, highlighting the importance of early diagnosis and treatment.
PID Serval
serval:BIB_9722D8509BAC
PMID
Open Access
Oui
Date de création
2014-01-14T13:52:37.097Z
Date de création dans IRIS
2025-05-21T03:16:35Z
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REF.pdf
Version du manuscrit
published
Taille
475.9 KB
Format
Adobe PDF
PID Serval
serval:BIB_9722D8509BAC.P001
URN
urn:nbn:ch:serval-BIB_9722D8509BAC9
Somme de contrôle
(MD5):14599381ddafbdbb1af87602a901a9ac