Titre
Region-selective control of the thalamic reticular nucleus via cortical layer 5 pyramidal cells.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Hádinger, N.
Auteure/Auteur
Bősz, E.
Auteure/Auteur
Tóth, B.
Auteure/Auteur
Vantomme, G.
Auteure/Auteur
Lüthi, A.
Auteure/Auteur
Acsády, L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1546-1726
Statut éditorial
Publié
Date de publication
2023-01
Volume
26
Numéro
1
Première page
116
Dernière page/numéro d’article
130
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Corticothalamic pathways, responsible for the top-down control of the thalamus, have a canonical organization such that every cortical region sends output from both layer 6 (L6) and layer 5 (L5) to the thalamus. Here we demonstrate a qualitative, region-specific difference in the organization of mouse corticothalamic pathways. Specifically, L5 pyramidal cells of the frontal cortex, but not other cortical regions, establish monosynaptic connections with the inhibitory thalamic reticular nucleus (TRN). The frontal L5-TRN pathway parallels the L6-TRN projection but has distinct morphological and physiological features. The exact spike output of the L5-contacted TRN cells correlated with the level of cortical synchrony. Optogenetic perturbation of the L5-TRN connection disrupted the tight link between cortical and TRN activity. L5-driven TRN cells innervated thalamic nuclei involved in the control of frontal cortex activity. Our data show that frontal cortex functions require a highly specialized cortical control over intrathalamic inhibitory processes.
PID Serval
serval:BIB_4030813AB165
PMID
Open Access
Oui
Date de création
2023-01-03T14:58:39.209Z
Date de création dans IRIS
2025-05-20T18:01:19Z
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Nom
Hadinger_etal_NatureNeuroscience_2023.pdf
Version du manuscrit
preprint
Licence
https://creativecommons.org/licenses/by/4.0
Taille
12.19 MB
Format
Adobe PDF
PID Serval
serval:BIB_4030813AB165.P001
Somme de contrôle
(MD5):38289372316483f21e4e85be650b1fa1