Titre
Acute effect of a dual ETA-ETB receptor antagonist on pulmonary arterial vasculature in preterm lamb fetuses with surgically induced diaphragmatic hernia
Type
article
Institution
Externe
Périodique
Auteur(s)
Stathopoulos, E.
Auteure/Auteur
Rolland, P. H.
Auteure/Auteur
Hery, G.
Auteure/Auteur
de Magnee, C.
Auteure/Auteur
Paut, O.
Auteure/Auteur
Couchot, E.
Auteure/Auteur
Lepretre, O.
Auteure/Auteur
Guys, J. M.
Auteure/Auteur
de Lagausie, P.
Auteure/Auteur
Liens vers les personnes
ISSN
1437-9813
Statut éditorial
Publié
Date de publication
2011-03
Volume
27
Numéro
3
Première page
295
Dernière page/numéro d’article
301
Peer-reviewed
Oui
Langue
anglais
Notes
Stathopoulos, Eleuthere
Rolland, Pierre-Henri
Hery, Geraldine
de Magnee, Catherine
Paut, Olivier
Couchot, Emmanuelle
Lepretre, Olivier
Guys, Jean-Michel
de Lagausie, Pascal
eng
Germany
Pediatr Surg Int. 2011 Mar;27(3):295-301. doi: 10.1007/s00383-010-2668-4. Epub 2010 Aug 10.
Rolland, Pierre-Henri
Hery, Geraldine
de Magnee, Catherine
Paut, Olivier
Couchot, Emmanuelle
Lepretre, Olivier
Guys, Jean-Michel
de Lagausie, Pascal
eng
Germany
Pediatr Surg Int. 2011 Mar;27(3):295-301. doi: 10.1007/s00383-010-2668-4. Epub 2010 Aug 10.
Résumé
PURPOSE: To study the effects of tezosentan, a dual ETA and ETB receptor antagonist on the cardiopulmonary profile in a fetal lamb model of CDH in utero. METHODS: A diaphragmatic hernia was surgically created at day 75 of gestation. During 45 min of tezosentan perfusion (1 mg/kg), hemodynamic parameters (pulmonary and aortic pressures, left pulmonary and aortic flows, left auricle pressure, heart rate) were measured at day 135 of gestation. Age-matched fetal lambs served as control animals. Secondarily, parietal tension of vessels rings of pulmonary arteries was assessed in organ baths under increasing concentration of tezosentan. RESULTS: In CDH group, under perfusion of tezosentan, pulmonary artery pressure decreased from 45.8 +/- 4.1 to 37.6 +/- 5.9 mmHg (P < 0.05). Pulmonary artery flow and pulmonary vascular resistance remained constant. In control group, pulmonary artery flow increased from 153.9 +/- 15.8 to 233.4 +/- 26 ml/min (P < 0.05). Pulmonary artery pressure did not vary. Subsequently calculated pulmonary vascular resistance decreased. In organ bath, no significant relaxation was observed. CONCLUSION: In this fetal lamb model of CDH, tezosentan decreased pulmonary artery pressure but did not modify pulmonary blood flow. Endothelin may play a role in the regulation of pulmonary vascular tone in utero.
Sujets
PID Serval
serval:BIB_C83B6860D191
PMID
Date de création
2021-05-17T19:12:15.173Z
Date de création dans IRIS
2025-05-21T02:27:47Z