Titre
Three-year follow-up of the first prospective randomized comparison between paclitaxel and sirolimus stents: the TAXi-LATE trial
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Berger, A.
Auteure/Auteur
Stauffer, J. C.
Auteure/Auteur
Seydoux, C.
Auteure/Auteur
Siegenthaler, M.
Auteure/Auteur
Benoit, A.
Auteure/Auteur
Goy, J. J.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1522-1946
Statut éditorial
Publié
Date de publication
2007-08
Volume
70
Numéro
2
Première page
163
Dernière page/numéro d’article
6
Notes
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
Résumé
GOAL: Analysis of the 3-year outcome of the original population of the TAXi trial which compared the efficacy of the paclitaxel (PES) and the sirolimus (SES) stents in a randomized "real world" investigation. HISTORY: The widespread use of drug-eluting stents strongly modified the world of interventional cardiology. The TAXi trial was a randomized comparison between PES and SES and showed similar efficacy between the two prostheses. Recently, emerging discussions raised questions about potential long-term risk with the use of DES. The present work attempts to describe the long-term outcome of the patients compared during the TAXi trial. METHOD: During April 2003 and January 2004, 202 patients were prospectively randomly assigned to the PES group (102 patients) and to the SES group (100 patients). The primary aim of the present investigation was the comparison of combined incidence of cardiac death, myocardial infarction, and target lesion revascularization within 36-months. RESULTS: No difference in mortality of all causes was noted in the PES and the SES groups (3% vs. 7%, P=0.98) or in major adverse cardiac event free survival (89% vs. 83%, P=0.28). Four stent thromboses were observed, two in the PES group (205 and 788 days) and two in the SES group (210 and 772 days). CONCLUSION: The long-term outcome analysis of the TAXi trial confirms available published data showing the equivalence of PES and SES on clinical basis.
Sujets
PID Serval
serval:BIB_9CF884EDBE50
PMID
Date de création
2008-01-28T09:11:23.981Z
Date de création dans IRIS
2025-05-20T22:08:58Z