Titre
Protection From Varicella Zoster in Solid Organ Transplant Recipients Carrying Killer Cell Immunoglobulin-Like Receptor B Haplotypes.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Schmied, L.
Auteure/Auteur
Terszowski, G.
Auteure/Auteur
Gonzalez, A.
Auteure/Auteur
Schmitter, K.
Auteure/Auteur
Hirsch, H.H.
Auteure/Auteur
Garzoni, C.
Auteure/Auteur
van Delden, C.
Auteure/Auteur
Boggian, K.
Auteure/Auteur
Mueller, N.J.
Auteure/Auteur
Berger, C.
Auteure/Auteur
Villard, J.
Auteure/Auteur
Manuel, O.
Auteure/Auteur
Meylan, P.
Auteure/Auteur
Hess, C.
Auteure/Auteur
Stern, M.
Auteure/Auteur
Contributrices/contributeurs
Achermann, R.
Aubert, JD.
Baumann, P.
Beldi, G.
Benden, C.
Berger, C.
Berney, T.
Binet, I.
Bochud, PY.
Boely, E.
Bucher, H.
Bühler, L.
Carell, T.
Catana, E.
Chalandon, Y.
de Geest, S.
de Rougemont, O.
Dickenmann, M.
Duchosal, M.
Fehr, T.
Ferrari-Lacraz, S.
Garzoni, C.
Gasche, Y.
Soccal, PG.
Giostra, E.
Golshayan, D.
Good, D.
Hadaya, K.
Hess, C.
Hillinger, S.
Hirsch, H.
Hofbauer, G.
Huynh-Do, U.
Immer, F.
Klaghofer, R.
Koller, M.
Kuntzen, T.
Laesser, B.
Lehmann, R.
Lovis, C.
Manuel, O.
Marti, HP.
Martin, PY.
Meylan, P.
Mohacsi, P.
Morard, I.
Morel, P.
Mueller, U.
Mueller, N.
Mueller-McKenna, H.
Müller, T.
Müllhaupt, B.
Nadal, D.
Nair, G.
Pascual, M.
Passweg, J.
Ziegler, CP.
Rick, J.
Roosnek, E.
Rosselet, A.
Rothlin, S.
Ruschitzka, F.
Schanz, U.
Schaub, S.
Seiler, C.
Semmo, N.
Stampf, S.
Steiger, J.
Tsinalis, D.
Van Delden, C.
Venetz, JP.
Villard, J.
Wick, M.
Wilhlem, M.
Yerly, P.
Groupes de travail
Swiss Transplant Cohort Study
Liens vers les personnes
Liens vers les unités
ISSN
1534-6080
Statut éditorial
Publié
Date de publication
2015
Volume
99
Numéro
12
Première page
2651
Dernière page/numéro d’article
2655
Peer-reviewed
Oui
Langue
anglais
Résumé
BACKGROUND: Natural killer cell function is regulated by inhibitory and activating killer cell immunoglobulin-like receptors (KIR). Previous studies have documented associations of KIR genotype with the risk of cytomegalovirus (CMV) replication after solid organ transplantation.
METHODS: In this study of 649 solid organ transplant recipients, followed prospectively for infectious disease events within the Swiss Transplant Cohort Study, we were interested to see if KIR genotype associated with virus infections other than CMV.
RESULT: We found that KIR B haplotypes (which have previously been linked to protection from CMV replication) were associated with protection from varicella zoster virus infection (hazard ratio, 0.43; 95% confidence interval, 0.21-0.91; P = 0.03). No significant associations were detected regarding the risk of herpes simplex, Epstein-Barr virus or BK polyomavirus infections.
CONCLUSIONS: In conclusion, these data provide evidence that the relative protection of KIR haplotype B from viral replication after solid organ transplantation may extend beyond CMV to other herpes viruses, such as varicella zoster virus and possibly Epstein-Barr virus.
METHODS: In this study of 649 solid organ transplant recipients, followed prospectively for infectious disease events within the Swiss Transplant Cohort Study, we were interested to see if KIR genotype associated with virus infections other than CMV.
RESULT: We found that KIR B haplotypes (which have previously been linked to protection from CMV replication) were associated with protection from varicella zoster virus infection (hazard ratio, 0.43; 95% confidence interval, 0.21-0.91; P = 0.03). No significant associations were detected regarding the risk of herpes simplex, Epstein-Barr virus or BK polyomavirus infections.
CONCLUSIONS: In conclusion, these data provide evidence that the relative protection of KIR haplotype B from viral replication after solid organ transplantation may extend beyond CMV to other herpes viruses, such as varicella zoster virus and possibly Epstein-Barr virus.
Sujets
PID Serval
serval:BIB_53EDE710E344
PMID
Date de création
2016-03-01T17:35:39.867Z
Date de création dans IRIS
2025-05-20T20:20:45Z