Titre
NPY Y1 receptor is not involved in the hemodynamic response to an acute cold pressor test in mice.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Cavadas, C.
Auteure/Auteur
Waeber, B.
Auteure/Auteur
Pedrazzini, T.
Auteure/Auteur
Grand, D.
Auteure/Auteur
Aubert, J.F.
Auteure/Auteur
Buclin, T.
Auteure/Auteur
Grouzmann, E.
Auteure/Auteur
Liens vers les personnes
ISSN
0196-9781
Statut éditorial
Publié
Date de publication
2007
Volume
28
Numéro
2
Première page
315
Dernière page/numéro d’article
319
Peer-reviewed
Oui
Langue
anglais
Résumé
The vasoconstrictor neuropeptide Y (NPY) has been shown to down-regulate tyrosine hydroxylase expression in cultured adrenal chromaffin cells, which probably accounts for the higher plasma resting norepinephrine (NE) and epinephrine (E) concentrations observed in Y(1) knock-out mice (Y(1)-/-) than in wild-type mice (Y(1)+/+). The aim of this work was to study the hemodynamic response of Y(1)-/- mice to an acute stimulation of the sympathetic nervous system (cold pressor test, CPT). Plasma catecholamine concentrations were higher in Y(1)-/- mice than in wild-type animals at the end of the CPT. The CPT-induced increase in mean arterial blood pressure (MAP) and heart rate (HR) was similar in both genotypes. Independently of the genotype, females had significantly slower HR than males throughout the 15min duration of the CPT. There was no difference in the sensitivity of the baroreceptor reflex, as reflected by the change in HR divided by the concurrent change in MBP between Y(1)-/- and Y(1)+/+ mice. In conclusion, mice lacking the Y(1) receptor can maintain normal hemodynamic response to an acute activation of the sympathetic system, albeit at the expense of increased catecholamine discharge.
PID Serval
serval:BIB_844EE50A3071
PMID
Date de création
2008-01-25T07:45:17.948Z
Date de création dans IRIS
2025-05-21T04:40:52Z