Titre
Multiple functions of Notch signaling in self-renewing organs and cancer
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Wilson, A.
Auteure/Auteur
Radtke, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0014-5793
Statut éditorial
Publié
Date de publication
2006-05
Volume
580
Numéro
12
Première page
2860
Dernière page/numéro d’article
8
Notes
Journal Article
Review --- Old month value: May 22
Review --- Old month value: May 22
Résumé
In recent years a substantial body of evidence has accumulated to support the notion that signaling pathways known to be important during embryonic development play important roles in regulating self-renewing tissues. Moreover, the same pathways are often deregulated during tumorigenesis due to mutations of key elements of these pathways. The Notch signaling cascade meets all of the above-mentioned criteria. We discuss here the pleiotropic roles of the Notch signaling pathway in three different self-renewing organs (intestine, hematopoietic system and skin) and how its deregulation is involved in tumorigenesis.
Sujets
PID Serval
serval:BIB_F4023301891A
PMID
Open Access
Oui
Date de création
2008-01-28T10:39:26.540Z
Date de création dans IRIS
2025-05-21T06:15:09Z