Titre
Effect of Obesity among Hospitalized Cancer Patients with or without COVID-19 on a National Level.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Cottenet, J.
Auteure/Auteur
Tapia, S.
Auteure/Auteur
Arveux, P.
Auteure/Auteur
Bernard, A.
Auteure/Auteur
Dabakuyo-Yonli, T.S.
Auteure/Auteur
Quantin, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2072-6694
Statut éditorial
Publié
Date de publication
2022-11-17
Volume
14
Numéro
22
Première page
5660
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Cancer and obesity are well-known prognostic factors in COVID-19. Our objective was to study the effect of obesity (and its severity) on the risk of intensive care unit (ICU) admission, severe complications, and in-hospital mortality, in a population of cancer patients hospitalized with or without COVID-19. All patients hospitalized in France for cancer from 1 March 2020 to 28 February 2022 were included from the French national administrative database. The effect of obesity was estimated in COVID-19 and in non-COVID-19 cancer patients using logistic and survival regressions, taking into account age, sex, comorbidities, and different types of cancer. Among the 992,899 cancer patients, we identified 53,090 patients with COVID-19 (5.35%), of which 3260 were obese (6.1%). After adjustment, for patients with or without COVID-19, there is an increased risk of ICU admission or severe complications in obese patients, regardless of the type of obesity. Regarding in-hospital mortality, there is no excess risk associated with overall obesity. However, massive obesity appears to be associated with an increased risk of in-hospital mortality, with a significantly stronger effect in solid cancer patients without COVID-19 and a significantly stronger effect in hematological cancer patients with COVID-19. This study showed that in France, among hospitalized patients with cancer and with or without COVID-19, increased vigilance is needed for obese patients, both in epidemic and non-epidemic periods. This vigilance should be further strengthened in patients with massive obesity for whom the risk of in-hospital mortality is higher, particularly in epidemic periods for patients with hematological cancers.
PID Serval
serval:BIB_65DFC9D28F76
PMID
Open Access
Oui
Date de création
2022-12-01T13:50:14.688Z
Date de création dans IRIS
2025-05-20T21:21:30Z
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Nom
36428751_BIB_65DFC9D28F76.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
323.81 KB
Format
Adobe PDF
PID Serval
serval:BIB_65DFC9D28F76.P001
URN
urn:nbn:ch:serval-BIB_65DFC9D28F760
Somme de contrôle
(MD5):535af5aeb87914b7827fa86eb7644b66