Titre
Role of amoxicillin serum levels for successful prophylaxis of experimental endocarditis due to tolerant streptococci.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Fluckiger, U.
Auteure/Auteur
Francioli, P.
Auteure/Auteur
Blaser, J.
Auteure/Auteur
Glauser, M.P.
Auteure/Auteur
Moreillon, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0022-1899
Statut éditorial
Publié
Date de publication
1994
Volume
169
Numéro
6
Première page
1397
Dernière page/numéro d’article
1400
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The importance of amoxicillin serum profiles for successful prophylaxis of experimental endocarditis in rats was assessed. Animals with catheter-induced vegetations were challenged intravenously with large inocula of Streptococcus sanguis and received one of the following amoxicillin dosages: single or multiple bolus injection of 40 mg/kg; 40 mg/kg administered as a continuous infusion over 12 h; or either 9 or 18 mg/kg administered over 12 or 24 h, respectively. The regimen producing a single transient high peak serum level failed to prevent experimental endocarditis; in contrast, a second injection 6 h after the first resulted in successful prophylaxis. Likewise, the three regimens of continuous, relatively low-dose regimens prevented infections. Thus, the most important parameter for successful prophylaxis was the duration of inhibitory concentration of the drug in the serum. The total dose of antibiotic, the peak serum levels, or the area-under-the-curve values were not predictive of successful prophylaxis.
PID Serval
serval:BIB_4001AD1F5087
PMID
Open Access
Oui
Date de création
2008-01-24T12:58:08.060Z
Date de création dans IRIS
2025-05-20T17:28:05Z
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Nom
REF.pdf
Version du manuscrit
published
Taille
415.93 KB
Format
Adobe PDF
PID Serval
serval:BIB_4001AD1F5087.P001
URN
urn:nbn:ch:serval-BIB_4001AD1F50872
Somme de contrôle
(MD5):2877006198440a9618ac98dfeda5ad3b