Titre
Follicular fluid lipoproteins in preovulatory period and their relationship with follicular maturation and progesterone production by human granulosa-luteal cells in vivo and in vitro.
Type
article
Institution
Externe
Périodique
Auteur(s)
Volpe, A.
Auteure/Auteur
Coukos, G.
Auteure/Auteur
Uccelli, E.
Auteure/Auteur
Droghini, F.
Auteure/Auteur
Adamo, R.
Auteure/Auteur
Artini, P.G.
Auteure/Auteur
Liens vers les personnes
ISSN
0391-4097
Statut éditorial
Publié
Date de publication
1991
Volume
14
Numéro
9
Première page
737
Dernière page/numéro d’article
742
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Follicular fluid (FF) lipoprotein content was evaluated in an in vitro fertilization/embryo transfer and gamete--intrafallopian--transfer program and correlated to follicular and oocyte maturation. Moreover, the in vitro progesterone response of granulosa-luteal cells from 10 patients to high-density lipoprotein (HDL) and to low-density lipoprotein (LDL) was assessed. Most FFs contained only HDL. Sixteen out of 97 FFs contained also very low levels of LDL and very-low-density lipoprotein (VLDL). The presence of LDL was associated to features of follicle and oocyte hypermaturity. LDL alone induced a much more potent increase of progesterone (P) release by granulosa-luteal cells than HDL alone, and the HDL partially reversed the potent effect of LDL. It is concluded that in late follicular phase HDL maintains P release by granulosa cells at a low rate and prevents a potent stimulation of P production by LDL which might cross the maturating blood-follicle barrier, until increasing passage of LDL in FF decreases the HDL:LDL ratio and the action of LDL becomes prominent.
PID Serval
serval:BIB_2623B0ED3713
PMID
Date de création
2014-10-14T10:42:44.791Z
Date de création dans IRIS
2025-05-20T17:19:19Z