Titre
Immunosurveillance encounters cancer metabolism.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Chuang, Y.M.
Auteure/Auteur
Tzeng, S.F.
Auteure/Auteur
Ho, P.C.
Auteure/Auteur
Tsai, C.H.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1469-3178
Statut éditorial
Publié
Date de publication
2024-02
Volume
25
Numéro
2
Première page
471
Dernière page/numéro d’article
488
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Tumor cells reprogram nutrient acquisition and metabolic pathways to meet their energetic, biosynthetic, and redox demands. Similarly, metabolic processes in immune cells support host immunity against cancer and determine differentiation and fate of leukocytes. Thus, metabolic deregulation and imbalance in immune cells within the tumor microenvironment have been reported to drive immune evasion and to compromise therapeutic outcomes. Interestingly, emerging evidence indicates that anti-tumor immunity could modulate tumor heterogeneity, aggressiveness, and metabolic reprogramming, suggesting that immunosurveillance can instruct cancer progression in multiple dimensions. This review summarizes our current understanding of how metabolic crosstalk within tumors affects immunogenicity of tumor cells and promotes cancer progression. Furthermore, we explain how defects in the metabolic cascade can contribute to developing dysfunctional immune responses against cancers and discuss the contribution of immunosurveillance to these defects as a feedback mechanism. Finally, we highlight ongoing clinical trials and new therapeutic strategies targeting cellular metabolism in cancer.
PID Serval
serval:BIB_A1C1A9A9C8FE
PMID
Open Access
Oui
Date de création
2024-01-18T13:59:41.727Z
Date de création dans IRIS
2025-05-20T21:42:03Z
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Nom
38216787.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.94 MB
Format
Adobe PDF
PID Serval
serval:BIB_A1C1A9A9C8FE.P001
URN
urn:nbn:ch:serval-BIB_A1C1A9A9C8FE2
Somme de contrôle
(MD5):d5783ca20f0017ab52b0e0b1d81e9e17