Titre
Superoxide anion is a natural inhibitor of FAS-mediated cell death.
Type
article
Institution
Externe
Périodique
Auteur(s)
Clément, M.V.
Auteure/Auteur
Stamenkovic, I.
Auteure/Auteur
Liens vers les personnes
ISSN
0261-4189[print], 0261-4189[linking]
Statut éditorial
Publié
Date de publication
1996
Volume
15
Numéro
2
Première page
216
Dernière page/numéro d’article
225
Langue
anglais
Résumé
The cell surface receptor Fas is a major trigger of apoptosis. However, expression of the Fas receptor in many tumor cell types does not correlate with sensitivity to Fas-mediated cell death. Because a prooxidant state is a common feature of tumor cells, we examined the role of intracellular reactive oxygen intermediates in the regulation of Fas-mediated cytotoxicity. Our results show that an oxidative stress induced by increasing the intracellular superoxide anion (O2-) concentration can abrogate Fas-mediated apoptosis in cells which are constitutively sensitive to Fas. Conversely, an O2- concentration decrease is observed to sensitize cells which are naturally resistant to Fas signals. These observations suggest that intracellular O2- may play a key role in regulating cell sensitivity to a potentially lethal signal and provide tumor cells with a natural, inducible mechanism of resistance to Fas-mediated apoptosis.
Sujets
PID Serval
serval:BIB_4DBE343E62F3
PMID
Date de création
2010-08-26T15:46:56.773Z
Date de création dans IRIS
2025-05-20T20:24:00Z