Titre
The protein acetylome and the regulation of metabolism.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Xing, S.
Auteure/Auteur
Poirier, Y.
Auteure/Auteur
Liens vers les personnes
ISSN
1878-4372
Statut éditorial
Publié
Date de publication
2012
Volume
17
Numéro
7
Première page
423
Dernière page/numéro d’article
430
Peer-reviewed
Oui
Langue
anglais
Résumé
Acetyl-coenzyme A (CoA) is a central metabolite involved in numerous anabolic and catabolic pathways, as well as in protein acetylation. Beyond histones, a large number of metabolic enzymes are acetylated in both animal and bacteria, and the protein acetylome is now emerging in plants. Protein acetylation is influenced by the cellular level of both acetyl-CoA and NAD(+), and regulates the activity of several enzymes. Acetyl-CoA is thus ideally placed to act as a key molecule linking the energy balance of the cell to the regulation of gene expression and metabolic pathways via the control of protein acetylation. Better knowledge over how to influence acetyl-CoA levels and the acetylation process promises to be an invaluable tool to control metabolic pathways.
PID Serval
serval:BIB_58C3A63279BC
PMID
Date de création
2012-12-19T08:13:47.551Z
Date de création dans IRIS
2025-05-20T15:34:30Z
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BIB_58C3A63279BC.P001.pdf
Version du manuscrit
published
Taille
422.14 KB
Format
Adobe PDF
PID Serval
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Somme de contrôle
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