Titre
The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations.
Type
article
Institution
Externe
Périodique
Auteur(s)
Hall, D.
Auteure/Auteur
Gogos, J.A.
Auteure/Auteur
Karayiorgou, M.
Auteure/Auteur
Liens vers les personnes
ISSN
1601-1848
Statut éditorial
Publié
Date de publication
2004
Volume
3
Numéro
4
Première page
240
Dernière page/numéro d’article
248
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
Here we characterize and compare the contribution of three recently identified strong candidate schizophrenia susceptibility genes; G72, neuregulin 1 (NRG1) and dystrobrevin-binding protein 1 (DTNBP1) in two independent datasets of patients with distinct genetic backgrounds. On the basis of corrected P-values from single- and multilocus transmission distortion tests our analysis provides no support for a contribution of G72, NRG1 or DTNBP1 in the tested samples. When transmission of individual haplotypes was considered, a picture more consistent with the original studies emerged, where transmission distortions in the same direction as the original samples and involving the same core haplotypes were observed for G72 and NRG1. Interestingly, whereas the NRG1 gene analysis was dominated by the presence of over-transmitted haplotypes, the G72 gene analysis was consistently dominated in both datasets by under-transmissions. Negative transmissions involved a core haplotype complementary to the originally detected over-transmitted haplotype, suggesting the presence of a protective variant within the G72 locus.
PID Serval
serval:BIB_301BA1B0C008
PMID
Open Access
Oui
Date de création
2012-02-27T15:23:11.156Z
Date de création dans IRIS
2025-05-20T14:01:33Z