Titre
Longitudinal analysis of white matter and cortical lesions in multiple sclerosis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Fartaria, M.J.
Auteure/Auteur
Kober, T.
Auteure/Auteur
Granziera, C.
Auteure/Auteur
Bach Cuadra, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2213-1582
Statut éditorial
Publié
Date de publication
2019
Volume
23
Première page
101938
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The goals of this study were to assess the performance of a novel lesion segmentation tool for longitudinal analyses, as well as to validate the generated lesion progression map between two time points using conventional and non-conventional MR sequences.
The lesion segmentation approach was evaluated with (LeMan-PV) and without (LeMan) the partial volume framework using "conventional" and "non-conventional" MR imaging in a two-year follow-up prospective study of 32 early RRMS patients. Manual segmentations of new, enlarged, shrunken, and stable lesions were used to evaluate the performance of the method variants. The true positive rate was estimated for those lesion evolutions in both white matter and cortex. The number of false positives was compared with two strategies for longitudinal analyses. New lesion tissue volume estimation was evaluated using Bland-Altman plots. Wilcoxon signed-rank test was used to evaluate the different setups.
The best median of the true positive rate was obtained using LeMan-PV with non-conventional sequences (P < .05): 87%, 87%, 100%, 83%, for new, enlarged, shrunken, and stable WM lesions, and 50%, 60%, 50%, 80%, for new, enlarged, shrunken, and stable cortical lesions, respectively. Most of the missed lesions were below the mean lesion size in each category. Lesion progression maps presented a median of 0 false positives (range:0-9) and the partial volume framework improved the volume estimation of new lesion tissue.
LeMan-PV exhibited the best performance in the detection of new, enlarged, shrunken and stable WM lesions. The method showed lower performance in the detection of cortical lesions, likely due to their low occurrence, small size and low contrast with respect to surrounding tissues. The proposed lesion progression map might be useful in clinical trials or clinical routine.
The lesion segmentation approach was evaluated with (LeMan-PV) and without (LeMan) the partial volume framework using "conventional" and "non-conventional" MR imaging in a two-year follow-up prospective study of 32 early RRMS patients. Manual segmentations of new, enlarged, shrunken, and stable lesions were used to evaluate the performance of the method variants. The true positive rate was estimated for those lesion evolutions in both white matter and cortex. The number of false positives was compared with two strategies for longitudinal analyses. New lesion tissue volume estimation was evaluated using Bland-Altman plots. Wilcoxon signed-rank test was used to evaluate the different setups.
The best median of the true positive rate was obtained using LeMan-PV with non-conventional sequences (P < .05): 87%, 87%, 100%, 83%, for new, enlarged, shrunken, and stable WM lesions, and 50%, 60%, 50%, 80%, for new, enlarged, shrunken, and stable cortical lesions, respectively. Most of the missed lesions were below the mean lesion size in each category. Lesion progression maps presented a median of 0 false positives (range:0-9) and the partial volume framework improved the volume estimation of new lesion tissue.
LeMan-PV exhibited the best performance in the detection of new, enlarged, shrunken and stable WM lesions. The method showed lower performance in the detection of cortical lesions, likely due to their low occurrence, small size and low contrast with respect to surrounding tissues. The proposed lesion progression map might be useful in clinical trials or clinical routine.
Sujets
PID Serval
serval:BIB_3DC1BC02419D
PMID
Open Access
Oui
Date de création
2019-09-24T12:22:57.348Z
Date de création dans IRIS
2025-05-20T16:32:38Z
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Nom
31491829_BIB_3DC1BC02419D.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
3.31 MB
Format
Adobe PDF
PID Serval
serval:BIB_3DC1BC02419D.P001
URN
urn:nbn:ch:serval-BIB_3DC1BC02419D7
Somme de contrôle
(MD5):6035471ab1ddf708910180632c3e2481