Titre
Crossing boundaries: stem cells, holoclones, and the fundamentals of squamous epithelial renewal
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Barrandon, Y.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0277-3740
Statut éditorial
Publié
Date de publication
2007-10
Volume
26
Numéro
9 Suppl 1
Première page
S10
Dernière page/numéro d’article
2
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
Renewal of stratified squamous epithelia, eg, the epidermis, the esophagus, or the epithelia lining the oral cavity, normally depends on the presence of keratinocyte stem cells that are thoroughly distributed in the epithelial basal layer. It is commonly thought that stem cells divide asymmetrically and generate transient amplifying cells. In turn, the latter generate postmitotic cells, which will replace the terminally differentiated cells that constantly slough off the epithelial surface. In this model, each stem cell only renews a tiny epithelial column, even if it has the capacity to generate a large amount of epithelium, a property important during wound healing. Interestingly, the cornea is an exception among stratified epithelia, because it does not contain stem cells but rather relies on the centripetal migration of transient amplifying cells generated by stem cells dividing occasionally and located at the limbus, the transition zone of the cornea with the conjunctiva. It is unclear which evolutionary advantage an epithelium with a rapid turn over has gained through the development of such a mechanism. Understanding why and how the cornea has evolved differently from all other stratified epithelia is certainly a major challenge in epithelial stem cell biology.
PID Serval
serval:BIB_17480533C0D2
PMID
Date de création
2008-01-28T07:41:56.800Z
Date de création dans IRIS
2025-05-20T17:40:32Z