Titre
The multifaceted role of cell cycle regulators in the coordination of growth and metabolism.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Huber, K.
Auteure/Auteur
Mestres-Arenas, A.
Auteure/Auteur
Fajas, L.
Auteure/Auteur
Leal-Esteban, L.C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1742-4658
Statut éditorial
Publié
Date de publication
2021-06
Volume
288
Numéro
12
Première page
3813
Dernière page/numéro d’article
3833
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi-directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the family of cyclin-dependent kinases (CDKs), their regulatory subunits known as cyclins, CDK inhibitors, the retinoblastoma family members, and the E2F transcription factors). Deciphering the mechanisms accountable for this coordination is crucial for understanding various patho-physiological processes. While it is well established that metabolism and growth affect cell division, this review will focus on recent observations that demonstrate how cell cycle regulators coordinate metabolism, cell cycle progression, and growth. We will discuss how the cell cycle regulators directly regulate metabolic enzymes and pathways and summarize their involvement in the endolysosomal pathway and in the functions and dynamics of mitochondria.
Sujets
PID Serval
serval:BIB_71F450E7C4FC
PMID
Open Access
Oui
Date de création
2020-10-26T06:38:58.523Z
Date de création dans IRIS
2025-05-20T21:55:21Z
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Nom
33030287_BIB_71F450E7C4FC.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc/4.0
Taille
1.16 MB
Format
Adobe PDF
PID Serval
serval:BIB_71F450E7C4FC.P001
URN
urn:nbn:ch:serval-BIB_71F450E7C4FC4
Somme de contrôle
(MD5):d66cb64c3dcaea52ab7b5fa833d3d558