Titre
Blood lactose after dairy product intake in healthy men.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Pimentel, G.
Auteure/Auteur
Burton, K.J.
Auteure/Auteur
Rosikiewicz, M.
Auteure/Auteur
Freiburghaus, C.
Auteure/Auteur
von Ah, U.
Auteure/Auteur
Münger, L.H.
Auteure/Auteur
Pralong, F.P.
Auteure/Auteur
Vionnet, N.
Auteure/Auteur
Greub, G.
Auteure/Auteur
Badertscher, R.
Auteure/Auteur
Vergères, G.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1475-2662
Statut éditorial
Publié
Date de publication
2017-12
Volume
118
Numéro
12
Première page
1070
Dernière page/numéro d’article
1077
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Publication Status: ppublish
Résumé
The absence of a dedicated transport for disaccharides in the intestine implicates that the metabolic use of dietary lactose relies on its prior hydrolysis at the intestinal brush border. Consequently, lactose in blood or urine has mostly been associated with specific cases in which the gastrointestinal barrier is damaged. On the other hand, lactose appears in the blood of lactating women and has been detected in the blood and urine of healthy men, indicating that the presence of lactose in the circulation of healthy subjects is not incompatible with normal physiology. In this cross-over study we have characterised the postprandial kinetics of lactose, and its major constituent, galactose, in the serum of fourteen healthy men who consumed a unique dose of 800 g milk or yogurt. Genetic testing for lactase persistence and microbiota profiling of the subjects were also performed. Data revealed that lactose does appear in serum after dairy intake, although with delayed kinetics compared with galactose. Median serum concentrations of approximately 0·02 mmol/l lactose and approximately 0·2 mmol/l galactose were observed after the ingestion of milk and yogurt respectively. The serum concentrations of lactose were inversely correlated with the concentrations of galactose, and the variability observed between the subjects' responses could not be explained by the presence of the lactase persistence allele. Finally, lactose levels have been associated with the abundance of the Veillonella genus in faecal microbiota. The measurement of systemic lactose following dietary intake could provide information about lactose metabolism and nutrient transport processes under normal or pathological conditions.
Sujets
PID Serval
serval:BIB_45226C6B180A
PMID
Open Access
Oui
Date de création
2017-12-07T19:33:43.022Z
Date de création dans IRIS
2025-05-20T16:05:52Z
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Nom
29198188.pdf
Version du manuscrit
published
Taille
946.19 KB
Format
Adobe PDF
PID Serval
serval:BIB_45226C6B180A.P001
URN
urn:nbn:ch:serval-BIB_45226C6B180A2
Somme de contrôle
(MD5):22280df0a411e8d05e7c4fed5c808e19