Titre
Lipid-loaded macrophages as new therapeutic target in cancer.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Marelli, G.
Auteure/Auteur
Morina, N.
Auteure/Auteur
Portale, F.
Auteure/Auteur
Pandini, M.
Auteure/Auteur
Iovino, M.
Auteure/Auteur
Di Conza, G.
Auteure/Auteur
Ho, P.C.
Auteure/Auteur
Di Mitri, D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2051-1426
Statut éditorial
Publié
Date de publication
2022-07
Volume
10
Numéro
7
Première page
e004584
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Macrophages are main players of the innate immune system. They show great heterogeneity and play diverse functions that include support to development, sustenance of tissue homeostasis and defense against infections. Dysfunctional macrophages have been described in multiple pathologies including cancer. Indeed tumor-associated macrophages (TAMs) are abundant in most tumors and sustain cancer growth, promote invasion and mediate immune evasion. Importantly, lipid metabolism influences macrophage activation and lipid accumulation confers pathogenic features on macrophages. Notably, a subset of lipid-loaded macrophages has been recently identified in many tumor types. Lipid-loaded TAMs support tumor growth and progression and exert immune-suppressive activities. In this review, we describe the role of lipid metabolism in macrophage activation in physiology and pathology and we discuss the impact of lipid accumulation in macrophages in the context of cancer.
PID Serval
serval:BIB_FD2BFB720D7B
PMID
Open Access
Oui
Date de création
2022-07-19T12:03:34.106Z
Date de création dans IRIS
2025-05-21T07:14:13Z
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Nom
35798535_BIB_FD2BFB720D7B.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc/4.0
Taille
1.39 MB
Format
Adobe PDF
PID Serval
serval:BIB_FD2BFB720D7B.P001
URN
urn:nbn:ch:serval-BIB_FD2BFB720D7B9
Somme de contrôle
(MD5):3c70f786bd6dcccd80e812ef4a459a88