Titre
The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Van der Does, D.
Auteure/Auteur
Boutrot, F.
Auteure/Auteur
Engelsdorf, T.
Auteure/Auteur
Rhodes, J.
Auteure/Auteur
McKenna, J.F.
Auteure/Auteur
Vernhettes, S.
Auteure/Auteur
Koevoets, I.
Auteure/Auteur
Tintor, N.
Auteure/Auteur
Veerabagu, M.
Auteure/Auteur
Miedes, E.
Auteure/Auteur
Segonzac, C.
Auteure/Auteur
Roux, M.
Auteure/Auteur
Breda, A.S.
Auteure/Auteur
Hardtke, C.S.
Auteure/Auteur
Molina, A.
Auteure/Auteur
Rep, M.
Auteure/Auteur
Testerink, C.
Auteure/Auteur
Mouille, G.
Auteure/Auteur
Höfte, H.
Auteure/Auteur
Hamann, T.
Auteure/Auteur
Zipfel, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1553-7404
Statut éditorial
Publié
Date de publication
2017-06
Volume
13
Numéro
6
Première page
e1006832
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Plants actively perceive and respond to perturbations in their cell walls which arise during growth, biotic and abiotic stresses. However, few components involved in plant cell wall integrity sensing have been described to date. Using a reverse-genetic approach, we identified the Arabidopsis thaliana leucine-rich repeat receptor kinase MIK2 as an important regulator of cell wall damage responses triggered upon cellulose biosynthesis inhibition. Indeed, loss-of-function mik2 alleles are strongly affected in immune marker gene expression, jasmonic acid production and lignin deposition. MIK2 has both overlapping and distinct functions with THE1, a malectin-like receptor kinase previously proposed as cell wall integrity sensor. In addition, mik2 mutant plants exhibit enhanced leftward root skewing when grown on vertical plates. Notably, natural variation in MIK2 (also named LRR-KISS) has been correlated recently to mild salt stress tolerance, which we could confirm using our insertional alleles. Strikingly, both the increased root skewing and salt stress sensitivity phenotypes observed in the mik2 mutant are dependent on THE1. Finally, we found that MIK2 is required for resistance to the fungal root pathogen Fusarium oxysporum. Together, our data identify MIK2 as a novel component in cell wall integrity sensing and suggest that MIK2 is a nexus linking cell wall integrity sensing to growth and environmental cues.
Sujets
PID Serval
serval:BIB_98C05114EB35
PMID
Open Access
Oui
Date de création
2017-06-22T16:27:11.862Z
Date de création dans IRIS
2025-05-20T22:35:44Z
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Nom
journal.pgen.1006832.pdf
Version du manuscrit
preprint
Taille
7.41 MB
Format
Adobe PDF
PID Serval
serval:BIB_98C05114EB35.P001
URN
urn:nbn:ch:serval-BIB_98C05114EB359
Somme de contrôle
(MD5):b6fd054e2f9947740f14dd1c9fa36010