Titre
Effect of aldosterone on the excretion of lithium in the adrenalectomized rat
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Horisberger, J. D.
Auteure/Auteur
Diezi, J.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0031-6768
Statut éditorial
Publié
Date de publication
1983-11
Volume
399
Numéro
3
Première page
213
Dernière page/numéro d’article
215
Notes
Journal Article
Résumé
The effect of aldosterone (1 microgram/kg X h) on the urinary excretion of lithium (Li) was measured by clearance studies in adrenalectomized rats receiving a glucocorticoid substitution (dexamethasone 6.6 micrograms/kg). Aldosterone induced significant anti-natriuresis and kaliuresis. The fractional excretion of Li remained constant around 28% and was not modified by aldosterone during the experiment (4 h). These results indicate that the tubular reabsorption of Li is not directly dependent on mineralocorticoid hormones. The previously reported effects of long term administration of DOCA or spironolactone of Li excretion are probably secondary to modifications of the sodium balance which, in turn, influences the proximal Li reabsorption rate.
Sujets
PID Serval
serval:BIB_98B99C34DD5C
PMID
Date de création
2008-01-24T11:38:44.680Z
Date de création dans IRIS
2025-05-20T23:43:28Z