Titre
Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry Study.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Pedrosa-Naudín, M.A.
Auteure/Auteur
Gutiérrez-Abejón, E.
Auteure/Auteur
Herrera-Gómez, F.
Auteure/Auteur
Fernández-Lázaro, D.
Auteure/Auteur
Álvarez, F.J.
Auteure/Auteur
Liens vers les unités
ISSN
1999-4923
Statut éditorial
Publié
Date de publication
2022-12-02
Volume
14
Numéro
12
Première page
2696
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Antidepressants are a commonly prescribed psychotropic medication, and their use has increased in recent years. Medication non-adherence in patients with mental disorders is associated with worse health outcomes. A population-based registry study to assess antidepressant non-adherence during 2021 has been carried out. An indirect method based on the medication possession ratio (MPR) has been utilized. Patients with a MPR under 80% were classified as non-adherent. A multivariate logistic regression to identify non-adherence predictors has been used, considering sociodemographic (age, sex, institutionalization and urbanicity) and health related variables (diagnostics, antidepressant class, multiple prescribers, and polypharmacy). In 2021, 10.6% of the Castile and Leon population used antidepressants. These patients were institutionalized (7.29%), living in urban areas (63.44%), polymedicated with multiple prescribers (57.07%), and using serotonin selective reuptake inhibitors (SSRIs) (54.77%), other antidepressants (46.82%) or tricyclic antidepressants (TCAs) (13.76%). Antidepressants were prescribed mainly for depression (36.73%) and anxiety (29.24%). Non-adherence to antidepressants was more frequent in men (20.56%) than in woman (19.59%) and decreased with increasing age (32% up to 17 years old vs. 13.76% over 80 years old). TCAs were associated with the highest prevalence of non-adherence (23.99%), followed by SSRIs (20.19%) and other antidepressants (18.5%). Predictors of non-adherence in patients on antidepressants were: living in urban areas, using TCAs, and pain occurrence. Non-adherence to antidepressants decreases with aging. Being female, institutionalization, being polymedicated and having depression/anxiety alongside another psychiatric diagnosis are protective factors against non-adherence. The MPR is a robust indicator for the clinician to identify non-adherent patients for monitoring, and adopt any necessary corrective actions.
PID Serval
serval:BIB_1C3B329E5C86
PMID
Open Access
Oui
Date de création
2023-01-03T14:52:16.415Z
Date de création dans IRIS
2025-05-20T19:09:34Z
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Nom
36559190_BIB_1C3B329E5C86.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
940.13 KB
Format
Adobe PDF
PID Serval
serval:BIB_1C3B329E5C86.P001
URN
urn:nbn:ch:serval-BIB_1C3B329E5C867
Somme de contrôle
(MD5):6b7414996bd1a879bb6f85167c4ebfbe