Titre
Clinical outcome after IMSI procedure in an unselected infertile population: a pilot study.
Type
article
Institution
Externe
Périodique
Auteur(s)
Marci, R.
Auteure/Auteur
Murisier, F.
Auteure/Auteur
Lo Monte, G.
Auteure/Auteur
Soave, I.
Auteure/Auteur
Chanson, A.
Auteure/Auteur
Urner, F.
Auteure/Auteur
Germond, M.
Auteure/Auteur
Liens vers les personnes
ISSN
1742-4755
Statut éditorial
Publié
Date de publication
2013-03-22
Volume
10
Première page
16
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: epublish
Publication Status: epublish
Résumé
To date the IMSI procedure represents the only real-time and unstained method available to discard spermatozoa with ultrastructural defects. Several studies demonstrated that IMSI provides positive results in couples with severe male factor infertility or repeated ICSI failures. Aim of this pilot study is to evaluate the differences between IMSI and ICSI in terms of IVF outcomes in an unselected infertile patient population.
Three hundred and thirty-two couples were analyzed: 281 couples underwent conventional ICSI procedure and 51 underwent IMSI technique.
No statistically significant differences were found between implantation rate (ICSI: 16,83%; IMSI: 16,67%), fertilization rate (ICSI: 77,27%; IMSI: 80,00%) and pregnancy rate (ICSI: 25,30%; IMSI: 23,50%). Both groups were comparable when considering live birth rate (ICSI: 11,39%; IMSI:13,72%), ongoing pregnancy rate (ICSI: 7,47%; IMSI: 5,88%) and miscarriage rate (ICSI: 17,78; IMSI: 5,26%). The subgroup analyses did not show a statistical difference between ICSI and IMSI neither in male factor infertility subgroup nor in patients with more than one previous ICSI attempt. A trend towards better laboratory and clinical outcomes was detected in the male factor infertility subgroup when IMSI was applied.
Our preliminary results show that the IMSI technique does not significantly improve IVF outcomes in an unselected infertile population.
Three hundred and thirty-two couples were analyzed: 281 couples underwent conventional ICSI procedure and 51 underwent IMSI technique.
No statistically significant differences were found between implantation rate (ICSI: 16,83%; IMSI: 16,67%), fertilization rate (ICSI: 77,27%; IMSI: 80,00%) and pregnancy rate (ICSI: 25,30%; IMSI: 23,50%). Both groups were comparable when considering live birth rate (ICSI: 11,39%; IMSI:13,72%), ongoing pregnancy rate (ICSI: 7,47%; IMSI: 5,88%) and miscarriage rate (ICSI: 17,78; IMSI: 5,26%). The subgroup analyses did not show a statistical difference between ICSI and IMSI neither in male factor infertility subgroup nor in patients with more than one previous ICSI attempt. A trend towards better laboratory and clinical outcomes was detected in the male factor infertility subgroup when IMSI was applied.
Our preliminary results show that the IMSI technique does not significantly improve IVF outcomes in an unselected infertile population.
PID Serval
serval:BIB_A6ADC840C053
PMID
Open Access
Oui
Date de création
2013-06-21T14:02:46.378Z
Date de création dans IRIS
2025-05-21T00:15:31Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
BIB_A6ADC840C053.P001.pdf
Version du manuscrit
preprint
Taille
225.33 KB
Format
Adobe PDF
PID Serval
serval:BIB_A6ADC840C053.P001
Somme de contrôle
(MD5):269d1580d46ce81fd18935c76d023490