Titre
Preoperative CT-Based Skeletal Muscle Mass Depletion and Outcomes after Total Laryngectomy.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Salati, V.
Auteure/Auteur
Mandralis, K.
Auteure/Auteur
Becce, F.
Auteure/Auteur
Koerfer, J.
Auteure/Auteur
Lambercy, K.
Auteure/Auteur
Simon, C.
Auteure/Auteur
Gorostidi, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2072-6694
Statut éditorial
Publié
Date de publication
2023-07-08
Volume
15
Numéro
14
Première page
3538
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
To assess the role of preoperative CT-based skeletal muscle mass depletion on postoperative clinical outcomes and survival in patients who underwent total laryngectomy for cancer.
Patients operated on between January 2011 and March 2020 were retrospectively included. Skeletal muscle area and intra- and inter-muscular fat accumulation were measured at the third lumbar vertebral level on preoperative CT scans. Skeletal muscle mass depletion was defined based on pre-established cut-off values. Their association with postoperative morbidity, length of stay (LOS), costs, and survival was assessed.
A total of 84 patients were included, of which 37 (44%) had preoperative skeletal muscle mass depletion. The rate of postoperative fistula (23% vs. 35%, p = 0.348), cutaneous cervical dehiscence (17% vs. 11%, p = 0.629), superficial incisional surgical site infections (SSI) (12% vs. 10%, p = 1.000), and unplanned reoperation (38% vs. 37%, p = 1.000) were comparable between the two patient groups. No difference in median LOS was observed (41 vs. 33 days, p = 0.295), nor in treatment costs (119,976 vs. 109,402 CHF, p = 0.585). The median overall survival was comparable between the two groups (3.43 vs. 4.95 years, p = 0.09).
Skeletal muscle mass depletion alone had no significant impact on postoperative clinical outcomes or survival.
Patients operated on between January 2011 and March 2020 were retrospectively included. Skeletal muscle area and intra- and inter-muscular fat accumulation were measured at the third lumbar vertebral level on preoperative CT scans. Skeletal muscle mass depletion was defined based on pre-established cut-off values. Their association with postoperative morbidity, length of stay (LOS), costs, and survival was assessed.
A total of 84 patients were included, of which 37 (44%) had preoperative skeletal muscle mass depletion. The rate of postoperative fistula (23% vs. 35%, p = 0.348), cutaneous cervical dehiscence (17% vs. 11%, p = 0.629), superficial incisional surgical site infections (SSI) (12% vs. 10%, p = 1.000), and unplanned reoperation (38% vs. 37%, p = 1.000) were comparable between the two patient groups. No difference in median LOS was observed (41 vs. 33 days, p = 0.295), nor in treatment costs (119,976 vs. 109,402 CHF, p = 0.585). The median overall survival was comparable between the two groups (3.43 vs. 4.95 years, p = 0.09).
Skeletal muscle mass depletion alone had no significant impact on postoperative clinical outcomes or survival.
PID Serval
serval:BIB_7B3B3DB948DE
PMID
Open Access
Oui
Date de création
2023-08-03T13:56:04.865Z
Date de création dans IRIS
2025-05-21T00:34:13Z
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Nom
37509201_BIB_7B3B3DB948DE.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
1.58 MB
Format
Adobe PDF
PID Serval
serval:BIB_7B3B3DB948DE.P001
URN
urn:nbn:ch:serval-BIB_7B3B3DB948DE0
Somme de contrôle
(MD5):e37702d49b1419efd2f60cc0d47db40a