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  4. Association of poorly controlled diabetes with low serum leptin in morbid obesity.
 
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Titre

Association of poorly controlled diabetes with low serum leptin in morbid obesity.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
International Journal of Obesity  
Auteur(s)
Clément, K.
Auteure/Auteur
Lahlou, N.
Auteure/Auteur
Ruiz, J.
Auteure/Auteur
Hager, J.
Auteure/Auteur
Bougnères, P.
Auteure/Auteur
Basdevant, A.
Auteure/Auteur
Guy-Grand, B.
Auteure/Auteur
Froguel, P.
Auteure/Auteur
Liens vers les personnes
Ruiz, Juan  
Liens vers les unités
Endocrinologie diabétologie&métabo.  
ISSN
0307-0565
Statut éditorial
Publié
Date de publication
1997
Volume
21
Numéro
7
Première page
556
Dernière page/numéro d’article
61
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
OBJECTIVES: Leptin may be involved in the regulation of body weight, food intake, and energy expenditure. In view of a possible link between leptin concentrations and diabetes that has been suggested in obese rodents, we investigated the potential relationship between serum leptin concentrations and hyperglycaemia in French patients with morbid obesity. SUBJECTS: Fasting leptin concentrations were measured in 241 morbidly obese patients with various degrees of glucose tolerance in a cross-sectional study. RESULTS: Fasting serum leptin concentrations did not differ between normoglycaemia (NG, 61.5 +/- 24.0 ng/ml) and glucose intolerant morbidly obese subjects (IGT, 56.5 +/- 18.5 ng/ml) and were slightly lower in those with controlled diabetes (55.1 +/- 30.3 ng/ml, P = 0.06 when compared to NG subjects). In contrast, leptin concentrations were 30% lower in patients with poorly controlled diabetes (43.0 +/- 22.2 ng/ml, P = 0.001 vs NG subjects). Leptin concentrations were negatively correlated with fasting glucose in all groups combined (p = -0.24, P = 0.0001) and particularly in NIDDM subjects (p = 0.31, P = 0.0054). Although leptin concentrations were higher in women than in men, similar significant correlation with fasting glucose was found when females were analyzed separately. A positive correlation was found with BMI (p = 0.25, P = 0.0001) in all groups. Multivariate analysis revealed that fasting glucose was independently associated with serum leptin concentrations (F = 12.5, P = 0.0005). Sex, age, BMI, waist/hip ratio, fasting glucose and insulin, total cholesterol and triglycerides, tested in the model, explained 42% of the leptin variability in this population. CONCLUSIONS: Poorly controlled diabetes was accompanied by a significant reduction of serum leptin concentrations in morbidly obese subjects. We suggest that a relative leptin deficiency (lower than expected for the BMI) associated with insulin deficiency in this population might contribute to a vicious cycle maintaining (or even worsening) obesity itself and/or its metabolic complications.
Sujets

Adult

Blood Glucose

Body Mass Index

Cross-Sectional Studi...

Diabetes Mellitus, Ty...

Fasting

Female

France

Humans

Insulin

Leptin

Male

Middle Aged

Obesity, Morbid

Proteins

Triglycerides

PID Serval
serval:BIB_EA833BB92A03
DOI
10.1038/sj.ijo.0800440
PMID
9226485
WOS
A1997XG08400006
Permalien
https://iris.unil.ch/handle/iris/230973
Open Access
Oui
Date de création
2008-03-03T14:16:43.261Z
Date de création dans IRIS
2025-05-21T05:10:34Z
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