Titre
Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. II. Changes during ischaemia.
Type
article
Institution
Externe
Périodique
Auteur(s)
Crockard, H.A.
Auteure/Auteur
Gadian, D.G.
Auteure/Auteur
Frackowiak, R.S.
Auteure/Auteur
Proctor, E.
Auteure/Auteur
Allen, K.
Auteure/Auteur
Williams, S.R.
Auteure/Auteur
Russell, R.W.
Auteure/Auteur
Liens vers les personnes
ISSN
0271-678X
Statut éditorial
Publié
Date de publication
1987
Volume
7
Numéro
4
Première page
394
Dernière page/numéro d’article
402
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
CBF has been measured with the hydrogen clearance technique in the two cerebral hemispheres of the gerbil under halothane anesthesia. This has been correlated with changes in local pH, tissue lactate, and phosphorus energy metabolites measured in the same animals with 1H and 31P nuclear magnetic resonance spectroscopy. We demonstrate a threshold flow value for the metabolic changes associated with energy failure at a level similar to the values previously reported for electrical failure and tissue water accumulation, but higher than that associated with breakdown of extracellular potassium homeostasis.
Sujets
PID Serval
serval:BIB_D5FCC4BD1B33
PMID
Date de création
2011-10-08T13:35:45.915Z
Date de création dans IRIS
2025-05-20T23:25:03Z