Titre
FDG-PET/ CT v diagnostice a hodnocení léčebné odpovědi Castlemanovy choroby – retrospektivní studie 29 případů z jednoho centra [FDG-PET/ CT for initial staging and response assessment in Castleman disease - retrospective single-center study of 29 cases]
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Klinicka onkologie
Auteur(s)
Koukalová, R.
Auteure/Auteur
Selingerová, I.
Auteure/Auteur
Řehák, Z.
Auteure/Auteur
Adam, Z.
Auteure/Auteur
Szturz, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1802-5307
Statut éditorial
Publié
Date de publication
2021
Volume
34
Numéro
2
Première page
120
Dernière page/numéro d’article
127
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Castleman disease (CD) is a rare lymphoproliferative disorder including unicentric and multicentric forms which can further be divided into four histopathologic variants (hyaline vascular, plasma cell, mixed, and plasmablastic). Multicentric CD typically behaves as an aggressive, relapsing entity with generalized lymphadenopathy and systemic symptoms. PET/CT following 18F-fluorodeoxyglucose administration (FDG-PET/CT) represents an imaging modality commonly used in malignant lymphomas for staging purposes and response assessment. However, literature data on its role in CD have been limited.
Twenty-nine patients, 18 men and 11 women, dia-gnosed in 1998-2016 were enrolled in our retrospective study. All patients underwent FDG-PET/CT during initial staging and/or as part of response assessment. We measured the maximum diameter of a lesion and established an index value corresponding to the ratio of the maximum standardized uptake value for the observed lesion and for the liver. The information about imaging examinations, patients, and disease extensions was put in a registry and statistically analyzed.
Unicentric and multicentric CD was dia-gnosed in 17 and 12 patients, respectively. Median age at the dia-gnosis was comparable between the two groups (51 and 58 years, respectively; P = 0.352). The majority of patients with multicentric CD (83%) were men. In women, the unicentric form prevailed (82 vs. 18%) while the difference between the two forms was of borderline significance in men (44 vs. 56%; P = 0.064). Most of the patients (88%) with unicentric CD had the hyaline vascular pathology type. On the contrary, the plasma cell type was predominant in multicentric CD (42%). The most commonly included anatomic sites included the retroperitoneum (52%) and the thorax (43%). Inguinal node involvement developed only in patients with multicentric CD. In repeatedly examined patients, FDG-PET/CT demonstrated a progressively decreasing size and metabolic activity of a selected lymph node.
FDG-PET/CT represents a suitable modality for initial staging and response monitoring of CD, especially in patients with a multicentric form.
Twenty-nine patients, 18 men and 11 women, dia-gnosed in 1998-2016 were enrolled in our retrospective study. All patients underwent FDG-PET/CT during initial staging and/or as part of response assessment. We measured the maximum diameter of a lesion and established an index value corresponding to the ratio of the maximum standardized uptake value for the observed lesion and for the liver. The information about imaging examinations, patients, and disease extensions was put in a registry and statistically analyzed.
Unicentric and multicentric CD was dia-gnosed in 17 and 12 patients, respectively. Median age at the dia-gnosis was comparable between the two groups (51 and 58 years, respectively; P = 0.352). The majority of patients with multicentric CD (83%) were men. In women, the unicentric form prevailed (82 vs. 18%) while the difference between the two forms was of borderline significance in men (44 vs. 56%; P = 0.064). Most of the patients (88%) with unicentric CD had the hyaline vascular pathology type. On the contrary, the plasma cell type was predominant in multicentric CD (42%). The most commonly included anatomic sites included the retroperitoneum (52%) and the thorax (43%). Inguinal node involvement developed only in patients with multicentric CD. In repeatedly examined patients, FDG-PET/CT demonstrated a progressively decreasing size and metabolic activity of a selected lymph node.
FDG-PET/CT represents a suitable modality for initial staging and response monitoring of CD, especially in patients with a multicentric form.
PID Serval
serval:BIB_EA9828F95E86
PMID
Open Access
Oui
Date de création
2024-12-28T17:34:17.185Z
Date de création dans IRIS
2025-05-21T05:10:36Z