Titre
Pattern formation in the Drosophila eye disc.
Type
synthèse (review)
Institution
Externe
Auteur(s)
Roignant, J.Y.
Auteure/Auteur
Treisman, J.E.
Auteure/Auteur
Liens vers les personnes
ISSN
1696-3547
Statut éditorial
Publié
Date de publication
2009
Volume
53
Numéro
5-6
Première page
795
Dernière page/numéro d’article
804
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Differentiation of the Drosophila compound eye from the eye imaginal disc is a progressive process: columns of cells successively differentiate in a posterior to anterior sequence, clusters of cells form at regularly spaced intervals within each column, and individual photoreceptors differentiate in a defined order within each cluster. The progression of differentiation across the eye disc is driven by a positive autoregulatory loop of expression of the secreted molecule Hedgehog, which is temporally delayed by the intercalation of a second signal, Spitz. Hedgehog refines the spatial position at which each column initiates its differentiation by inducing secondary signals that act over different ranges to control the expression of positive and negative regulators. The position of clusters within each column is controlled by secreted inhibitory signals from clusters in the preceding column, and a single founder neuron, R8, is singled out within each cluster by Notch-mediated lateral inhibition. R8 then sequentially recruits surrounding cells to differentiate by producing a short-range signal, Spitz, which induces a secondary short-range signal, Delta. Intrinsic transcription factors act in combination with these two signals to produce cell-type diversity within the ommatidium. The Hedgehog and Spitz signals are transported along the photoreceptor axons and reused within the brain as long-range and local cues to trigger the differentiation and assembly of target neurons.
Sujets
PID Serval
serval:BIB_40D05C9D20EB
PMID
Open Access
Oui
Date de création
2019-10-28T11:59:49.320Z
Date de création dans IRIS
2025-05-20T20:46:23Z