Titre
In vivo localisation of radiolabelled monoclonal antibody in human gliomas.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Behnke, J.
Auteure/Auteur
Mach, J.P.
Auteure/Auteur
Buchegger, F.
Auteure/Auteur
Carrel, S.
Auteure/Auteur
Delaloye, B.
Auteure/Auteur
De Tribolet, N.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0268-8697
Statut éditorial
Publié
Date de publication
1988
Volume
2
Numéro
2
Première page
193
Dernière page/numéro d’article
197
Peer-reviewed
Oui
Langue
anglais
Résumé
F(ab')2-fragments of the anti-melanoma monoclonal antibody MeI-14 were labelled with 123I for external scanning and with 125I for tissue measurement of radioactivity and injected intravenously into patients scheduled for surgical resection of a glioma. The paired-label study was performed by injecting simultaneously 131I-labelled control (F(ab')2-fragments. The patients were scanned by computerised tomoscintigraphy. After surgery, the activities of 125I and 131I were counted in tumour and normal tissues. The results indicate that there was a low but definite uptake of the antibody in the tumour due to its specificity. The external detection was difficult because of accumulation of antibody fragments in the skull.
PID Serval
serval:BIB_5C4DB3FA63E9
PMID
Date de création
2008-01-25T10:28:17.880Z
Date de création dans IRIS
2025-05-20T18:06:48Z