Titre
Inhibition Within the Lateral Habenula-Implications for Affective Disorders.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Webster, J.F.
Auteure/Auteur
Lecca, S.
Auteure/Auteur
Wozny, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1662-5153
Statut éditorial
Publié
Date de publication
2021
Volume
15
Première page
786011
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
The lateral habenula (LHb) is a key brain region implicated in the pathology of major depressive disorder (MDD). Specifically, excitatory LHb neurons are known to be hyperactive in MDD, thus resulting in a greater excitatory output mainly to downstream inhibitory neurons in the rostromedial tegmental nucleus. This likely results in suppression of downstream dopaminergic ventral tegmental area neurons, therefore, resulting in an overall reduction in reward signalling. In line with this, increasing evidence implicates aberrant inhibitory signalling onto LHb neurons as a co-causative factor in MDD, likely as a result of disinhibition of excitatory neurons. Consistently, growing evidence now suggests that normalising inhibitory signalling within the LHb may be a potential therapeutic strategy for MDD. Despite these recent advances, however, the exact pharmacological and neural circuit mechanisms which control inhibitory signalling within the LHb are still incompletely understood. Thus, in this review article, we aim to provide an up-to-date summary of the current state of knowledge of the mechanisms by which inhibitory signalling is processed within the LHb, with a view of exploring how this may be targeted as a future therapy for MDD.
PID Serval
serval:BIB_332FAC333FC5
PMID
Open Access
Oui
Date de création
2021-12-20T11:58:41.160Z
Date de création dans IRIS
2025-05-20T19:44:55Z
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Nom
34899206_BIB_332FAC333FC5.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
1.18 MB
Format
Adobe PDF
PID Serval
serval:BIB_332FAC333FC5.P001
URN
urn:nbn:ch:serval-BIB_332FAC333FC50
Somme de contrôle
(MD5):438b451efe38357bc9c2f2cbb7f4f118