Titre
Tissue plasminogen activator in psoriasis
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Jensen, P. J.
Auteure/Auteur
Baird, J.
Auteure/Auteur
Belin, D.
Auteure/Auteur
Vassalli, J. D.
Auteure/Auteur
Busso, N.
Auteure/Auteur
Gubler, P.
Auteure/Auteur
Lazarus, G. S.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0022-202X
Statut éditorial
Publié
Date de publication
1990-11
Volume
95
Numéro
5
Première page
13S
Dernière page/numéro d’article
14S
Notes
Journal Article
Review --- Old month value: Nov
Review --- Old month value: Nov
Résumé
Elevated levels of the serine proteinase plasminogen activator are observed in psoriatic lesions. In contrast to normal epidermis, lesional psoriatic epidermis contains primarily tissue type plasminogen activator (tPA) activity and much lower levels of urokinase type plasminogen activator (uPA) activity. Tissue plasminogen activator is also detectable immunocytochemically in lesional psoriatic but not normal epidermis. Similarly, mRNA for tPA is observed in lesional epidermis only. These results suggest that lesional psoriatic epidermis synthesizes enhanced levels of tPA compared to normal. Additional data support the hypothesis that enhanced tPA may be another marker common to psoriatic epidermis, epidermis during wound repair, and keratinocytes in culture. The significance of elevated tPA in psoriatic lesions is presently unclear, but its possible relationship to epidermal proliferation and cutaneous inflammation is under study.
Sujets
PID Serval
serval:BIB_18FB8F5B6AE5
PMID
Open Access
Oui
Date de création
2008-01-25T07:29:44.879Z
Date de création dans IRIS
2025-05-20T13:27:01Z