Titre

Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression: A neuroimaging meta-regression analysis.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Gunasekera, B.
Auteure/Auteur
Davies, C.
Auteure/Auteur
Blest-Hopley, G.
Auteure/Auteur
Veronese, M.
Auteure/Auteur
Ramsey, N.F.
Auteure/Auteur
Bossong, M.G.
Auteure/Auteur
Radua, J.
Auteure/Auteur
Bhattacharyya, S.
Auteure/Auteur
Contributrices/contributeurs
Pretzsch, C.
McAlonan, G.
Walter, C.
Lötsch, J.
Freeman, T.
Curran, V.
Battistella, G.
Fornari, E.
Filho, G.B.
Crippa, J.A.
Duran, F.
Zuardi, A.W.
Groupes de travail
CBE Consortium
Liens vers les unités
ISSN
1873-7528
Statut éditorial
Publié
Date de publication
2022-09
Volume
140
Première page
104801
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The neurobiological mechanisms underlying the effects of delta-9-tetrahydrocannabinol (THC) remain unclear. Here, we examined the spatial acute effect of THC on human regional brain activation or blood flow (hereafter called 'activation signal') in a 'core' network of brain regions from 372 participants, tested using a within-subject repeated measures design under experimental conditions. We also investigated whether the neuromodulatory effects of THC are related to the local expression of the cannabinoid-type-1 (CB1R) and type-2 (CB2R) receptors. Finally, we investigated the dose-response relationship between THC and key brain substrates. These meta-analytic findings shed new light on the localisation of the effects of THC in the human brain, suggesting that THC has neuromodulatory effects in regions central to many cognitive tasks and processes, related to dose, with greater effects in regions with higher levels of CB1R expression.
Sujets

Brain

Dronabinol

Gene Expression

Humans

Neuroimaging

Receptors, Cannabinoi...

Regression Analysis

Attention

Cannabis

FMRI

Memory

Meta-analysis

PET

Reward

Systematic

THC

Tetrahydrocannabinol

PID Serval
serval:BIB_1BBAB7FDA7B2
DOI
PMID
WOS
Permalien
Open Access
Oui
Date de création
2022-08-15T12:39:35.384Z
Date de création dans IRIS
2025-05-20T14:52:10Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression_ A neuroimaging meta-regression analysis.pdf

Version du manuscrit

published

Licence

https://creativecommons.org/licenses/by/4.0

Taille

10.73 MB

Format

Adobe PDF

PID Serval

serval:BIB_1BBAB7FDA7B2.P001

URN

urn:nbn:ch:serval-BIB_1BBAB7FDA7B21

Somme de contrôle

(MD5):34fffa37111c83b01d004a3197c33bbf