Titre
Peri-ictal heart rate variability parameters as surrogate markers of seizure severity.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Arbune, A.A.
Auteure/Auteur
Jeppesen, J.
Auteure/Auteur
Conradsen, I.
Auteure/Auteur
Ryvlin, P.
Auteure/Auteur
Beniczky, S.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1528-1167
Statut éditorial
Publié
Date de publication
2020-11
Volume
61 Suppl 1
Première page
S55
Dernière page/numéro d’article
S60
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
This study aims at defining objective parameters reflecting the severity of peri-ictal autonomic changes and their relation to post-ictal generalized electroencephalography (EEG) suppression (PGES), with the view that such changes could be detected by wearable seizure detection systems and prove useful to assess the risk of sudden unexpected death in epilepsy (SUDEP). To this purpose, we assessed peri-ictal changes in heart rate variability (HRV) and correlated them with seizure duration, intensity of electromyography-based ictal muscle activity, and presence and duration of post-ictal generalized EEG suppression (PGES). We evaluated 75 motor seizures from 40 patients, including 61 generalized tonic-clonic seizures (GTCS) and 14 other major motor seizure types. For all major motor seizures, HRV measurements demonstrated a significantly decreased parasympathetic activity and increased sympathetic activity in the post-ictal period. The post-ictal increased sympathetic activity was significantly higher for GTCS as compared with non-GTCS. The degree of peri-ictal decreased parasympathetic activity and increased sympathetic activity was associated with longer PGES (>20 s), longer seizure duration, and greater intensity of ictal muscle activity. Mean post-ictal heart rate (HR) was an independent predictor of PGES duration, seizure duration, and intensity of ictal muscle contraction. Our results indicate that peri-ictal changes in HRV are potential biomarkers of major motor seizure severity.
Sujets
PID Serval
serval:BIB_8DCC56BD04A6
PMID
Date de création
2020-06-10T20:56:26.115Z
Date de création dans IRIS
2025-05-21T00:08:07Z