Titre
Metabolically Healthy Obesity and High Carotid Intima-Media Thickness in Children and Adolescents: International Childhood Vascular Structure Evaluation Consortium.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Zhao, M.
Auteure/Auteur
López-Bermejo, A.
Auteure/Auteur
Caserta, C.A.
Auteure/Auteur
Medeiros, CCM
Auteure/Auteur
Kollias, A.
Auteure/Auteur
Bassols, J.
Auteure/Auteur
Romeo, E.L.
Auteure/Auteur
Ramos, TDA
Auteure/Auteur
Stergiou, G.S.
Auteure/Auteur
Yang, L.
Auteure/Auteur
Xargay-Torrent, S.
Auteure/Auteur
Amante, A.
Auteure/Auteur
Gusmão, TME
Auteure/Auteur
Grammatikos, E.
Auteure/Auteur
Zhang, Y.
Auteure/Auteur
Prats-Puig, A.
Auteure/Auteur
de Carvalho, D.F.
Auteure/Auteur
Yang, L.
Auteure/Auteur
Carreras-Badosa, G.
Auteure/Auteur
Simões, M.O.
Auteure/Auteur
Hou, Y.
Auteure/Auteur
Mas-Pares, B.
Auteure/Auteur
Shui, W.
Auteure/Auteur
Guo, T.
Auteure/Auteur
Wang, M.
Auteure/Auteur
Chen, H.
Auteure/Auteur
Lou, X.
Auteure/Auteur
Zhang, Q.
Auteure/Auteur
Zhang, Y.
Auteure/Auteur
Bovet, P.
Auteure/Auteur
Magnussen, C.G.
Auteure/Auteur
Xi, B.
Auteure/Auteur
Contributrices/contributeurs
Lizarraga-Mollinedo, E.
Diaz-Roldan, F.
Furtado da Costa, IFA
Lima de Farias, C.R.
Oliveira, R.C.
Medeiros, C.M.
Lira, J.M.
Psilopatis, I.
Karagiaouri, E.
Glaraki, M.
Grammatikos, E.E.
Dantas, R.R.
Aires, YRF
Barros de Melo, P.Y.
Cordeiro de Melo, E.M.
Ramalho, M.C.
Groupes de travail
International Childhood Vascular Structure Evaluation Consortium
Liens vers les personnes
Liens vers les unités
ISSN
1935-5548
Statut éditorial
Publié
Date de publication
2019-01
Volume
42
Numéro
1
Première page
119
Dernière page/numéro d’article
125
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy of CVD risk, in children and adolescents.
Data were available for 3,497 children and adolescents aged 6-17 years from five population-based cross-sectional studies in Brazil, China, Greece, Italy, and Spain. Weight status categories (normal, overweight, and obese) were defined using BMI cutoffs from the International Obesity Task Force. Metabolic status (defined as "healthy" [no risk factors] or "unhealthy" [one or more risk factors]) was based on four CVD risk factors: elevated blood pressure, elevated triglyceride levels, reduced HDL cholesterol, and elevated fasting glucose. High cIMT was defined as cIMT ≥90th percentile for sex, age, and study population. Logistic regression model was used to examine the association of weight and metabolic status with high cIMT, with adjustment for sex, age, race/ethnicity, and study center.
In comparison with metabolically healthy normal weight, odds ratios (ORs) for high cIMT were 2.29 (95% CI 1.58-3.32) for metabolically healthy overweight and 3.91 (2.46-6.21) for MHO. ORs for high cIMT were 1.44 (1.03-2.02) for unhealthy normal weight, 3.49 (2.51-4.85) for unhealthy overweight, and 6.96 (5.05-9.61) for unhealthy obesity.
Among children and adolescents, cIMT was higher for both MHO and metabolically healthy overweight compared with metabolically healthy normal weight. Our findings reinforce the need for weight control in children and adolescents irrespective of their metabolic status.
Data were available for 3,497 children and adolescents aged 6-17 years from five population-based cross-sectional studies in Brazil, China, Greece, Italy, and Spain. Weight status categories (normal, overweight, and obese) were defined using BMI cutoffs from the International Obesity Task Force. Metabolic status (defined as "healthy" [no risk factors] or "unhealthy" [one or more risk factors]) was based on four CVD risk factors: elevated blood pressure, elevated triglyceride levels, reduced HDL cholesterol, and elevated fasting glucose. High cIMT was defined as cIMT ≥90th percentile for sex, age, and study population. Logistic regression model was used to examine the association of weight and metabolic status with high cIMT, with adjustment for sex, age, race/ethnicity, and study center.
In comparison with metabolically healthy normal weight, odds ratios (ORs) for high cIMT were 2.29 (95% CI 1.58-3.32) for metabolically healthy overweight and 3.91 (2.46-6.21) for MHO. ORs for high cIMT were 1.44 (1.03-2.02) for unhealthy normal weight, 3.49 (2.51-4.85) for unhealthy overweight, and 6.96 (5.05-9.61) for unhealthy obesity.
Among children and adolescents, cIMT was higher for both MHO and metabolically healthy overweight compared with metabolically healthy normal weight. Our findings reinforce the need for weight control in children and adolescents irrespective of their metabolic status.
PID Serval
serval:BIB_9490A4971A5A
PMID
Date de création
2018-11-29T13:04:31.858Z
Date de création dans IRIS
2025-05-20T23:39:07Z