Titre

Modulation of C1-Inhibitor and Plasma Kallikrein Activities by Type IV Collagen.

Type
article
Institution
Externe
Périodique
Auteur(s)
Ravindran, S.
Auteure/Auteur
Schapira, M.
Auteure/Auteur
Patston, P.A.
Auteure/Auteur
Liens vers les personnes
ISSN
1687-8795
Statut éditorial
Publié
Date de publication
2012
Volume
2012
Première page
212417
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The contact system of coagulation can be activated when in contact with biomaterials. As collagen is being tested in novel biomaterials in this study, we have investigated how type IV collagen affects plasma kallikrein and C1-inhibitor. Firstly, we showed C1-inhibitor binds to type IV collagen with a Kd of 0.86 μM. The effects of type IV collagen on plasma kallikrein, factor XIIa, and β-factor XIIa activity and on C1-inhibitor function were determined. Factor XIIa rapidly lost activity in the presence of type IV collagen, whereas plasma kallikrein and β-factor XIIa were more stable. The rate of inhibition of plasma kallikrein by C1-inhibitor was decreased by type IV collagen in a dose-dependent manner. These studies could be relevant to the properties of biomaterials, which contain collagen, and should be considered in the testing for biocompatibility.
PID Serval
serval:BIB_3BF935394352
DOI
PMID
Permalien
Open Access
Oui
Date de création
2023-04-27T21:04:47.386Z
Date de création dans IRIS
2025-05-20T20:46:06Z
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22481936_BIB_3BF935394352.pdf

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published

Licence

https://creativecommons.org/licenses/by/4.0

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998.72 KB

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Adobe PDF

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serval:BIB_3BF935394352.P001

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