Titre
CD4 T lymphocyte proliferative responses to hepatitis C virus (HCV) antigens in patients coinfected with HCV and human immunodeficiency virus who responded to anti-HCV treatment
Type
article
Institution
Externe
Périodique
Auteur(s)
Legrand, E.
Auteure/Auteur
Neau, D.
Auteure/Auteur
Galperine, T.
Auteure/Auteur
Trimoulet, P.
Auteure/Auteur
Moreau, J. F.
Auteure/Auteur
Pitard, V.
Auteure/Auteur
Lacut, J. Y.
Auteure/Auteur
Ragnaud, J. M.
Auteure/Auteur
Dupon, M.
Auteure/Auteur
Le Bail, B.
Auteure/Auteur
Bernard, N.
Auteure/Auteur
Schvoerer, E.
Auteure/Auteur
Houghton, M.
Auteure/Auteur
Fleury, H.
Auteure/Auteur
Lafon, M. E.
Auteure/Auteur
Liens vers les personnes
ISSN
0022-1899
Statut éditorial
Publié
Date de publication
2002
Volume
186
Numéro
3
Première page
302
Dernière page/numéro d’article
11
Langue
anglais
Notes
Legrand, Elisabeth
Neau, Didier
Galperine, Tatiana
Trimoulet, Pascale
Moreau, Jean-Francois
Pitard, Vincent
Lacut, Jean-Yves
Ragnaud, Jean-Marie
Dupon, Michel
Le Bail, Brigitte
Bernard, Noelle
Schvoerer, Evelyne
Houghton, Michael
Fleury, Herve
Lafon, Marie-Edith
eng
Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
2002/07/23
J Infect Dis. 2002 Aug 1;186(3):302-11. doi: 10.1086/341659. Epub 2002 Jul 17.
Neau, Didier
Galperine, Tatiana
Trimoulet, Pascale
Moreau, Jean-Francois
Pitard, Vincent
Lacut, Jean-Yves
Ragnaud, Jean-Marie
Dupon, Michel
Le Bail, Brigitte
Bernard, Noelle
Schvoerer, Evelyne
Houghton, Michael
Fleury, Herve
Lafon, Marie-Edith
eng
Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
2002/07/23
J Infect Dis. 2002 Aug 1;186(3):302-11. doi: 10.1086/341659. Epub 2002 Jul 17.
Résumé
CD4 T lymphocyte proliferative responses to hepatitis C virus (HCV) antigens were evaluated before and during an anti-HCV regimen (interferon-alpha2a and ribavirin) in 36 patients coinfected with HCV and human immunodeficiency virus (HIV), to determine whether immune responses against HCV antigens are present in such patients, whether these responses are modified by anti-HCV treatment, and whether they are correlated with treatment efficacy. The CD4 responses against HCV antigens (primarily core antigens) detected at study entry in one-half of the patients did not correlate with anti-HCV treatment efficacy. Of 36 patients, 8 had patterns of persistent immune response to infection by genotypes 3 or 4 that were significantly correlated with sustained virologic response. Persistent immunologic reactivity and sustained virologic response coexisted only in patients infected with genotype 3. These findings suggest that HCV genotype may influence specific immune response, which, in turn, is implicated in virologic control.
Sujets
PID Serval
serval:BIB_5BD22996632F
PMID
Date de création
2023-01-30T10:16:47.000Z
Date de création dans IRIS
2025-05-20T15:10:45Z