Titre
Muscle-epidermis interactions affect exoskeleton patterning in Caenorhabditis elegans.
Type
article
Institution
Externe
Périodique
Auteur(s)
Broday, L.
Auteure/Auteur
Hauser, C.A.
Auteure/Auteur
Kolotuev, I.
Auteure/Auteur
Ronai, Z.
Auteure/Auteur
Liens vers les personnes
ISSN
1058-8388
Statut éditorial
Publié
Date de publication
2007-11
Volume
236
Numéro
11
Première page
3129
Dernière page/numéro d’article
3136
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The C. elegans hypodermis is a single epithelial cell layer separated from the musculature by a thin basement membrane on its basal surface. The hypodermis secretes the extracellular material of the cuticle from its apical surface. The regulation of cuticle synthesis and apical secretion is not well understood. UNC-95 is a component of the muscle dense bodies and M-lines, which are integrin-based adhesion complexes required for force transduction to the cuticle. Using gene expression profiling and in vivo assays, we show that, in unc-95 mutant worms, there is an increase in expression levels of a group of hypodermal and pharyngeal genes related to cuticle structure and molting. Moreover, the cuticle structure of unc-95 mutant adult is impaired. Our findings suggest that aberrant force transduction from the structurally impaired muscle attachments across the basement membrane to the underlying hypodermis elicits intercellular signaling that plays a role in regulating cuticle synthesis and patterning.
Sujets
PID Serval
serval:BIB_FE57A21429D7
PMID
Open Access
Oui
Date de création
2021-10-01T07:39:40.680Z
Date de création dans IRIS
2025-05-21T06:27:12Z
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Nom
Developmental Dynamics - 2007 - Broday - Muscle epidermis interactions affect exoskeleton patterning in Caenorhabditis.pdf
Version du manuscrit
published
Taille
565.04 KB
Format
Adobe PDF
PID Serval
serval:BIB_FE57A21429D7.P001
Somme de contrôle
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