Titre
Truly privacy-preserving federated analytics for precision medicine with multiparty homomorphic encryption.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Froelicher, D.
Auteure/Auteur
Troncoso-Pastoriza, J.R.
Auteure/Auteur
Raisaro, J.L.
Auteure/Auteur
Cuendet, M.A.
Auteure/Auteur
Sousa, J.S.
Auteure/Auteur
Cho, H.
Auteure/Auteur
Berger, B.
Auteure/Auteur
Fellay, J.
Auteure/Auteur
Hubaux, J.P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2041-1723
Statut éditorial
Publié
Date de publication
2021-10-11
Volume
12
Numéro
1
Première page
5910
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Using real-world evidence in biomedical research, an indispensable complement to clinical trials, requires access to large quantities of patient data that are typically held separately by multiple healthcare institutions. We propose FAMHE, a novel federated analytics system that, based on multiparty homomorphic encryption (MHE), enables privacy-preserving analyses of distributed datasets by yielding highly accurate results without revealing any intermediate data. We demonstrate the applicability of FAMHE to essential biomedical analysis tasks, including Kaplan-Meier survival analysis in oncology and genome-wide association studies in medical genetics. Using our system, we accurately and efficiently reproduce two published centralized studies in a federated setting, enabling biomedical insights that are not possible from individual institutions alone. Our work represents a necessary key step towards overcoming the privacy hurdle in enabling multi-centric scientific collaborations.
PID Serval
serval:BIB_3683F2C63090
PMID
Open Access
Oui
Date de création
2021-10-19T10:25:19.711Z
Date de création dans IRIS
2025-05-20T17:58:03Z
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Nom
34635645_BIB_3683F2C63090.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
1.36 MB
Format
Adobe PDF
PID Serval
serval:BIB_3683F2C63090.P001
URN
urn:nbn:ch:serval-BIB_3683F2C630902
Somme de contrôle
(MD5):52c65e1cfc652b97fd133319279d0731