Titre
Pharmacological stimulation of edar signaling in the adult enhances sebaceous gland size and function.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Kowalczyk-Quintas, C.
Auteure/Auteur
Schuepbach-Mallepell, S.
Auteure/Auteur
Willen, L.
Auteure/Auteur
Smith, T.K.
Auteure/Auteur
Huttner, K.
Auteure/Auteur
Kirby, N.
Auteure/Auteur
Headon, D.J.
Auteure/Auteur
Schneider, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1523-1747
Statut éditorial
Publié
Date de publication
2015
Volume
135
Numéro
2
Première page
359
Dernière page/numéro d’article
368
Langue
anglais
Résumé
Impaired ectodysplasin A (EDA) receptor (EDAR) signaling affects ectodermally derived structures including teeth, hair follicles, and cutaneous glands. The X-linked hypohidrotic ectodermal dysplasia (XLHED), resulting from EDA deficiency, can be rescued with lifelong benefits in animal models by stimulation of ectodermal appendage development with EDAR agonists. Treatments initiated later in the developmental period restore progressively fewer of the affected structures. It is unknown whether EDAR stimulation in adults with XLHED might have beneficial effects. In adult Eda mutant mice treated for several weeks with agonist anti-EDAR antibodies, we find that sebaceous gland size and function can be restored to wild-type levels. This effect is maintained upon chronic treatment but reverses slowly upon cessation of treatment. Sebaceous glands in all skin regions respond to treatment, although to varying degrees, and this is accompanied in both Eda mutant and wild-type mice by sebum secretion to levels higher than those observed in untreated controls. Edar is expressed at the periphery of the glands, suggesting a direct homeostatic effect of Edar stimulation on the sebaceous gland. Sebaceous gland size and sebum production may serve as biomarkers for EDAR stimulation, and EDAR agonists may improve skin dryness and eczema frequently observed in XLHED.
PID Serval
serval:BIB_5CBFC64D4700
PMID
Open Access
Oui
Date de création
2014-12-15T17:01:30.423Z
Date de création dans IRIS
2025-05-20T19:30:57Z
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Nom
BIB_5CBFC64D4700.P001.pdf
Version du manuscrit
preprint
Taille
2 MB
Format
Adobe PDF
PID Serval
serval:BIB_5CBFC64D4700.P001
URN
urn:nbn:ch:serval-BIB_5CBFC64D47006
Somme de contrôle
(MD5):e7dee7e6a39d1a40e09db14b78c53074