Titre
Insulin resistance, hyperglycemia, and glucosuria in intensively milk-fed calves
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Hostettler-Allen, R. L.
Auteure/Auteur
Tappy, L.
Auteure/Auteur
Blum, J. W.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0021-8812
Statut éditorial
Publié
Date de publication
1994-01
Volume
72
Numéro
1
Première page
160
Dernière page/numéro d’article
73
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
In intensively milk-fed calves post-prandial glucose (G) and insulin (I) concentrations, but not preprandial G concentrations, increased or failed to decrease during the growth period, compared with data from calves that were progressively weaned. This study was, therefore, designed to investigate G and I metabolism in veal calves. Euglycemic-hyperinsulinemic and hyperglycemic clamps in the unfed state demonstrated mutual responsiveness of I and G, but revealed a relative I resistance. After feed consumption, I resistance was exaggerated, as seen by decreased G clearance rates after i.v. G and I administration in fed compared with unfed calves. Milk replacer is a source of readily available lactose, fat, and protein, the intake of which, on a kilogram.75 basis, gradually increased with age. Increased substrate availability and effects of nutrients themselves were probably responsible for elevated plasma concentrations of G and I and led to I resistance. Additionally, hyperglycemia > 1.5 g/L was followed by urinary excretion of G.
Sujets
PID Serval
serval:BIB_602DFC91614A
PMID
Date de création
2008-01-24T12:36:10.521Z
Date de création dans IRIS
2025-05-20T20:05:25Z