Titre
Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Knecht, Z.A.
Auteure/Auteur
Silbering, A.F.
Auteure/Auteur
Cruz, J.
Auteure/Auteur
Yang, L.
Auteure/Auteur
Croset, V.
Auteure/Auteur
Benton, R.
Auteure/Auteur
Garrity, P.A.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2050-084X
Statut éditorial
Publié
Date de publication
2017-06-16
Volume
6
Première page
e26654
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Insects use hygrosensation (humidity sensing) to avoid desiccation and, in vectors such as mosquitoes, to locate vertebrate hosts. Sensory neurons activated by either dry or moist air ('dry cells' and 'moist cells') have been described in many insects, but their behavioral roles and the molecular basis of their hygrosensitivity remain unclear. We recently reported that <i>Drosophila</i> hygrosensation relies on three Ionotropic Receptors (IRs) required for dry cell function: IR25a, IR93a and IR40a (Knecht et al., 2016). Here, we discover <i>Drosophila</i> moist cells and show that they require IR25a and IR93a together with IR68a, a conserved, but orphan IR. Both IR68a- and IR40a-dependent pathways drive hygrosensory behavior: each is important for dry-seeking by hydrated flies and together they underlie moist-seeking by dehydrated flies. These studies reveal that humidity sensing in <i>Drosophila</i> , and likely other insects, involves the combined activity of two molecularly related but neuronally distinct hygrosensing systems.
PID Serval
serval:BIB_53097AE12AE5
PMID
Open Access
Oui
Date de création
2017-06-27T15:35:52.936Z
Date de création dans IRIS
2025-05-20T13:45:11Z
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Nom
elife-26654-v2.pdf
Version du manuscrit
published
Taille
3.64 MB
Format
Adobe PDF
PID Serval
serval:BIB_53097AE12AE5.P001
URN
urn:nbn:ch:serval-BIB_53097AE12AE52
Somme de contrôle
(MD5):e34249d7f2793fe3ac32595507c1e0d6