Titre
Long-term treatment of depression: is there a use for depot antidepressants?
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Baumann, P.
Auteure/Auteur
Bertschy, G.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0268-1315
Statut éditorial
Publié
Date de publication
1997-03
Volume
12
Numéro
2
Première page
77
Dernière page/numéro d’article
80
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Depot neuroleptics have been widely introduced for long-term treatment of schizophrenia. The question of whether depot antidepressants should be developed for the treatment of chronic depression and for the prophylaxis of recurrent depression is addressed. This approach seems to be indicated in patients showing poor compliance to oral antidepressive medication and in patients suffering from secondary depression and who are already receiving depot antipsychotics, but it is also indicated in subgroups of patients who, for social, cultural or personality reasons, have problems with regard to a regular and long-term intake of oral medication. Before the development of depot antidepressants is initiated, the ethical issues relating to this form of medication should be discussed. Technically, the preparation of depot forms may represent a serious challenge. Depot antipsychotics are all esters of hydroxylated neuroleptics and long-chain fatty acids. Potential candidates for antidepressants are venlafaxine, flesinoxan and E-10-OH-nortriptyline. The possibility of developing forms for transdermal application is also discussed. In conclusion, clinical considerations support the idea of the usefulness of a depot preparation for antidepressants but ethical and technical aspects should not be neglected.
PID Serval
serval:BIB_E4D597BBFBF0
PMID
Date de création
2021-01-12T15:16:56.017Z
Date de création dans IRIS
2025-05-21T05:28:16Z