Titre
Developing psychosis and its risk States through the lens of schizotypy.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Debbané, M.
Auteure/Auteur
Eliez, S.
Auteure/Auteur
Badoud, D.
Auteure/Auteur
Conus, P.
Auteure/Auteur
Flückiger, R.
Auteure/Auteur
Schultze-Lutter, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1745-1701
Statut éditorial
Publié
Date de publication
2015
Volume
41 Suppl 2
Première page
S396
Dernière page/numéro d’article
S407
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Starting from the early descriptions of Kraepelin and Bleuler, the construct of schizotypy was developed from observations of aberrations in nonpsychotic family members of schizophrenia patients. In contemporary diagnostic manuals, the positive symptoms of schizotypal personality disorder were included in the ultra high-risk (UHR) criteria 20 years ago, and nowadays are broadly employed in clinical early detection of psychosis. The schizotypy construct, now dissociated from strict familial risk, also informed research on the liability to develop any psychotic disorder, and in particular schizophrenia-spectrum disorders, even outside clinical settings. Against the historical background of schizotypy it is surprising that evidence from longitudinal studies linking schizotypy, UHR, and conversion to psychosis has only recently emerged; and it still remains unclear how schizotypy may be positioned in high-risk research. Following a comprehensive literature search, we review 18 prospective studies on 15 samples examining the evidence for a link between trait schizotypy and conversion to psychosis in 4 different types of samples: general population, clinical risk samples according to UHR and/or basic symptom criteria, genetic (familial) risk, and clinical samples at-risk for a nonpsychotic schizophrenia-spectrum diagnosis. These prospective studies underline the value of schizotypy in high-risk research, but also point to the lack of evidence needed to better define the position of the construct of schizotypy within a developmental psychopathology perspective of emerging psychosis and schizophrenia-spectrum disorders.
PID Serval
serval:BIB_D4FC3C25410B
PMID
Open Access
Oui
Date de création
2015-01-23T13:46:22.393Z
Date de création dans IRIS
2025-05-20T21:54:45Z
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Nom
BIB_D4FC3C25410B.P001.pdf
Version du manuscrit
preprint
Taille
391.15 KB
Format
Adobe PDF
PID Serval
serval:BIB_D4FC3C25410B.P001
Somme de contrôle
(MD5):2bf6fbd6d6555db4200b34f8a5d6e0b8