Titre
Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsy.
Type
article
Institution
Externe
Périodique
Auteur(s)
Nishino, S.
Auteure/Auteur
Tafti, M.
Auteure/Auteur
Reid, M.S.
Auteure/Auteur
Shelton, J.
Auteure/Auteur
Siegel, J.M.
Auteure/Auteur
Dement, W.C.
Auteure/Auteur
Mignot, E.
Auteure/Auteur
Liens vers les personnes
ISSN
0270-6474[print], 0270-6474[linking]
Statut éditorial
Publié
Date de publication
1995-07
Volume
15
Numéro
7 Pt 1
Première page
4806
Dernière page/numéro d’article
4814
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep-related symptoms, such as cataplexy. The exact pathophysiology underlying the disease is unknown but may involve central cholinergic systems. It is known that the brainstem cholinergic system is activated during REM sleep. Furthermore, REM sleep and REM sleep atonia similar to cataplexy can be triggered in normal and narcoleptic dogs by stimulating cholinergic receptors within the pontine brainstem. The pontine cholinergic system is, therefore, likely to play a role in triggering cataplexy and other REM-related abnormalities seen in narcolepsy. The other cholinergic system that could be involved in the pathophysiology of narcolepsy is located in the basal forebrain (BF). This system sends projections to the entire cerebral cortex. Since acetylcholine release in the cortex is increased both during REM and wake, the basocortical cholinergic system is believed to be involved in cortical desynchrony. In the current study, we analyzed the effect of cholinergic compounds injected into the forebrain structures of narcoleptic and control dogs. We found that carbachol (a cholinergic agonist) injected into the BF triggers cataplexy in narcoleptic dogs while it increases wakefulness in control dogs. Much higher doses of carbachol bilaterally injected in the BF were, however, shown to trigger muscle atonia even in control dogs. These results suggest that a cholinoceptive site in the BF is critically implicated in triggering muscle atonia and cataplexy. Together with similar results previously obtained in the pontine brainstem, it appears that a widespread hypersensitivity to cholinergic stimulation may be central to the pathophysiology of canine narcolepsy.(ABSTRACT TRUNCATED AT 250 WORDS)
PID Serval
serval:BIB_E7164D28F2D6
PMID
Date de création
2008-01-24T14:55:17.087Z
Date de création dans IRIS
2025-05-21T01:02:40Z