Titre
Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Spertini, F.
Auteure/Auteur
Chatila, T.
Auteure/Auteur
Geha, R. S.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0022-1767
Statut éditorial
Publié
Date de publication
1992-04
Volume
148
Numéro
7
Première page
2045
Dernière page/numéro d’article
9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr 1
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr 1
Résumé
We here demonstrate that ligand binding to MHC class I molecules induces homotypic cell adhesion of lymphocytes and monocytes. mAb to beta 2-microglobulin caused sustained, largely LFA-1-independent adhesion whereas mAb to the MHC class I alpha H chain caused transient LFA-1-dependent adhesion. Both the protein kinase C inhibitor sphingosine and the tyrosine kinase inhibitor genistein abrogated MHC class I-mediated cellular adhesion. These results indicate that MHC class I molecules transduce signals that induce cell adhesion and suggest that interaction between MHC class I-restricted T cells and APC may result in reciprocal enhanced adhesiveness of these cells.
Sujets
PID Serval
serval:BIB_FFFF67206791
PMID
Date de création
2008-01-25T14:19:29.959Z
Date de création dans IRIS
2025-05-21T07:03:25Z