Titre
Dynamics between insight and medication adherence in first-episode psychosis: Study of 3-year trajectories.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Elowe, J.
Auteure/Auteur
Ramain, J.
Auteure/Auteur
Solida, A.
Auteure/Auteur
Conus, P.
Auteure/Auteur
Golay, P.
Auteure/Auteur
Liens vers les personnes
ISSN
1778-3585
Statut éditorial
Publié
Date de publication
2022-08-15
Volume
65
Numéro
1
Première page
e49
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
While specialized early intervention programs represent the gold standard in terms of optimal management of first-episode psychosis (FEP), poor medication adherence remains a predominant unmet need in the treatment of psychosis. In this regard, an interaction between insight and adherence in FEP patients has been hypothesized but has been challenged by multiple pitfalls.
Latent profile analysis and trajectory modeling techniques were used to evaluate insight and adherence of 331 FEP patients engaged at the beginning, middle, and end of a 3-year specialized early psychosis program. A Bayesian model comparison approach was used to compare scores of clinical, functional, and socioeconomic outcomes at the end point of the study.
Nearly one-third of the patients maintain a high level of insight and adherence during the entire program. At the end of the 3-year follow-up, more than three-quarters of patients are considered adherent to their medication. Patients with low levels of insight and adherence at the beginning of the program improve first in terms of adherence and then of insight. Furthermore, patients with high levels of insight and adherence are most likely to reach functional recovery and to experience an increase in environmental quality of life.
Latent FEP subpopulations can be identified based on insight and adherence. Medication adherence was the first variable to improve, but a gain in insight possibly plays a role in the reinforcement of adherence.
Latent profile analysis and trajectory modeling techniques were used to evaluate insight and adherence of 331 FEP patients engaged at the beginning, middle, and end of a 3-year specialized early psychosis program. A Bayesian model comparison approach was used to compare scores of clinical, functional, and socioeconomic outcomes at the end point of the study.
Nearly one-third of the patients maintain a high level of insight and adherence during the entire program. At the end of the 3-year follow-up, more than three-quarters of patients are considered adherent to their medication. Patients with low levels of insight and adherence at the beginning of the program improve first in terms of adherence and then of insight. Furthermore, patients with high levels of insight and adherence are most likely to reach functional recovery and to experience an increase in environmental quality of life.
Latent FEP subpopulations can be identified based on insight and adherence. Medication adherence was the first variable to improve, but a gain in insight possibly plays a role in the reinforcement of adherence.
PID Serval
serval:BIB_055E7ACA7BBD
PMID
Open Access
Oui
Date de création
2022-06-27T08:15:26.386Z
Date de création dans IRIS
2025-05-20T15:16:35Z
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Nom
Elowe et al 2022.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
264.39 KB
Format
Adobe PDF
PID Serval
serval:BIB_055E7ACA7BBD.P001
URN
urn:nbn:ch:serval-BIB_055E7ACA7BBD6
Somme de contrôle
(MD5):3df2e6c12aa970fefa2a262256cbf4b0