Titre
Hyperacute graft rejection during heart transplantation for giant cell myocarditis: a case report.
Type
étude de cas
Institution
Externe
Périodique
Auteur(s)
Mutijima, E.
Auteure/Auteur
Delbecque, K.
Auteure/Auteur
Defraigne, J.O.
Auteure/Auteur
Bouillenne, C.
Auteure/Auteur
Damas, P.
Auteure/Auteur
Pierard, L.
Auteure/Auteur
Boniver, J.
Auteure/Auteur
de Leval, L.
Auteure/Auteur
Liens vers les personnes
ISSN
1618-0631
Statut éditorial
Publié
Date de publication
2010
Volume
206
Numéro
6
Première page
411
Dernière page/numéro d’article
414
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
We report the case of a patient with giant cell myocarditis who was bridged to transplantation with mechanical circulatory support and developed a fatal perioperative hyperacute rejection. The patient had received abundant transfusions that had raised her anti-HLA antibody titers. The cross-match test was positive. No pre-transplantation immunosuppressive therapy had been administered given concomitant infection. The severity and acuteness of the rejection in this case likely reflect the combined effect of preformed anti-HLA antibodies in the context of an active organ-specific immune process at the time of transplantation. This case raises the questions of the need for intensive immunosuppressive therapy before transplantation in giant cell myocarditis and of the management of patients with positive cross-match in the context of a giant cell myocarditis.
PID Serval
serval:BIB_F0B4388CC516
PMID
Date de création
2010-10-22T08:49:11.035Z
Date de création dans IRIS
2025-05-21T05:59:36Z