Titre
Trauma as triggering factor for development of melanocytic nevi.
Type
étude de cas
Institution
Externe
Périodique
Auteur(s)
Navarini, A.A.
Auteure/Auteur
Kolm, I.
Auteure/Auteur
Calvo, X.
Auteure/Auteur
Kamarashev, J.
Auteure/Auteur
Kerl, K.
Auteure/Auteur
Conrad, C.
Auteure/Auteur
French, L.E.
Auteure/Auteur
Braun, R.P.
Auteure/Auteur
Liens vers les personnes
ISSN
1421-9832
Statut éditorial
Publié
Date de publication
2010
Volume
220
Numéro
4
Première page
291
Dernière page/numéro d’article
296
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
The mechanisms for the development of acquired melanocytic nevi remain mostly unclear. Here we report a case of eruptive nevi that developed after localized superficial trauma, and review the currently known cellular and triggering factors for acquired melanocytic nevi. A 66-year-old woman presented a linear arrangement of pigmented macules on her left calf that developed after a bloodless skin erosion on the same spot, resulting from friction with the lining of a ski boot. Dermatopathology identified multiple junctional proliferations of single or small nest-forming melanocytes with bridging, pigment incontinence and moderate cellular atypia. The number of a person's nevi correlates with age, race and genetics, but blistering diseases, scarring processes, light exposure and immunosuppression can contribute to nevocellular growth as well. Damaged keratinocytes and inflammatory cells can release growth factors inducing nevus cell proliferation, and immunosuppression could end cellular surveillance keeping preexisting nevus cell nests in check. We conclude that in predisposed patients, the trigger for eruptive nevi can be reduced to a simple localized minor trauma.
PID Serval
serval:BIB_0E25E62431A5
PMID
Date de création
2012-03-26T09:27:27.067Z
Date de création dans IRIS
2025-05-20T17:40:53Z