Titre
The European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI)-clinical phenotypes and their predictors based on a cohort of 1000 patients.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Pappaccogli, M.
Auteure/Auteur
Di Monaco, S.
Auteure/Auteur
Warchoł-Celińska, E.
Auteure/Auteur
Lorthioir, A.
Auteure/Auteur
Amar, L.
Auteure/Auteur
Aparicio, L.S.
Auteure/Auteur
Beauloye, C.
Auteure/Auteur
Bruno, R.M.
Auteure/Auteur
Chenu, P.
Auteure/Auteur
de Leeuw, P.
Auteure/Auteur
De Backer, T.
Auteure/Auteur
Delmotte, P.
Auteure/Auteur
Dika, Z.
Auteure/Auteur
Gordin, D.
Auteure/Auteur
Heuten, H.
Auteure/Auteur
Iwashima, Y.
Auteure/Auteur
Krzesinski, J.M.
Auteure/Auteur
Kroon, A.A.
Auteure/Auteur
Mazzolai, L.
Auteure/Auteur
Poch, E.
Auteure/Auteur
Sarafidis, P.
Auteure/Auteur
Seinturier, C.
Auteure/Auteur
Spiering, W.
Auteure/Auteur
Toubiana, L.
Auteure/Auteur
Van der Niepen, P.
Auteure/Auteur
van Twist, D.
Auteure/Auteur
Visonà, A.
Auteure/Auteur
Wautrecht, J.C.
Auteure/Auteur
Witowicz, H.
Auteure/Auteur
Xu, J.
Auteure/Auteur
Prejbisz, A.
Auteure/Auteur
Januszewicz, A.
Auteure/Auteur
Azizi, M.
Auteure/Auteur
Persu, A.
Auteure/Auteur
Contributrices/contributeurs
Aparicio, L.S.
Persu, A.
Pappaccogli, M.
Beauloye, C.
Chenu, P.
Hammer, F.
Goffette, P.
Astarci, P.
Peeters, A.
Verhelst, R.
Vikkula, M.
Van der Niepen, P.
Van Tussenbroek, F.
De Backer, T.
Gevaert, S.
Hemelsoet, D.
Defreyne, L.
Heuten, H.
Yperzeele, L.
Van der Zijden, T.
Lengelé, J.P.
Krzesinski, J.M.
Sprynger, M.
Delmotte, P.
Verhamme, P.
Vanassche, T.
Scoppettuolo, P.
Wautrecht, J.C.
Vinck, W.
Dobrin, V.
Teodora, Y.
Wang, J.
Xu, J.
Jelaković, B.
Dika, Z.
Gordin, D.
Tikkanen, I.
Venermo, M.
Mäkelä, R.N.
Plouin, P.F.
Jeunemaitre, X.
Toubiana, L.
Azizi, M.
Amar, L.
Chédid, A.
Mousseaux, E.
Lorthioir, A.
Ormezzano, O.
Seinturier, C.
Thony, F.
Mahfoud, F.
Kulenthiran, S.
Sarafidis, P.
Piperidou, A.
Doumas, M.
Stergiou, G.S.
Vlahakos, D.
Canning, C.
Sharabi, Y.
Morganti, A.
Bruno, R.M.
Taddei, S.
Romanini, C.
Petrucci, I.
Rabbia, F.
Pappaccogli, M.
Di Monaco, S.
Rossi, G.P.
Lerco, S.
Minuz, P.
Mansueto, G.
De Marchi, S.
Marcon, D.
Salice, P.
Visonà, A.
Bigolin, P.
Zingaretti, V.
Cianci, R.
Zedde, M.
Matteucci, M.C.
Iwashima, Y.
Kawarada, O.
Kadoya, Y.
van Twist, D.J.
Kroon, B.
de Leeuw, P.
Spiering, W.
van den Born, B.J.
Høieggen, A.
Sommer, M.S.
Januszewicz, A.
Warchoł-Celińska, E.
Prejbisz, A.
Witkowski, A.
Witowicz, H.
Kądziela, J.
Soplińska, A.
Pieluszczak, K.
Jóżwik-Plebanek, K.
Januszewicz, M.
Florczak, E.
Dobrowolski, P.
Szabóová, E.
Hudák, M.
Moščovič, M.
Mediavilla, J.D.
Aguila, F.J.
Oliveras, A.
Segura, J.
Prado, J.C.
Robles, N.R.
Poch, E.
Montagud-Marrahi, E.
Molina, A.
Guillen, E.
Burrel, M.
De la Llama, P.F.
Barros-Membrilla, A.J.
Gottsäter, A.
Wuerzner, G.
Mazzolai, L.
Buso, G.
Jarraya, F.
Chaker, H.
Adlam, D.
Chrysochou, C.
Dhaun, N.
Hunter, R.W.
MacIntyre, I.
Webb, D.
Groupes de travail
European/International FMD Registry and Initiative (FEIRI), and the Working Group ‘Hypertension and the Kidney' of the European Society of Hypertension (ESH)
Liens vers les personnes
Liens vers les unités
ISSN
1755-3245
Statut éditorial
Publié
Date de publication
2021-02-22
Volume
117
Numéro
3
Première page
950
Dernière page/numéro d’article
959
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections.
All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 ± 16 years (12% ≥65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients ≥65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke, and multivessel FMD.
The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management, and follow-up of FMD.
All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 ± 16 years (12% ≥65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients ≥65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke, and multivessel FMD.
The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management, and follow-up of FMD.
PID Serval
serval:BIB_548DD62AB8B5
PMID
Date de création
2020-04-25T19:05:31.885Z
Date de création dans IRIS
2025-05-20T15:41:39Z